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光滑的无定形磷酸钙微球结晶为核壳型羟基磷灰石微球。

Crystallization of smooth amorphous calcium phosphate microspheres to core-shell hydroxyapatite microspheres.

作者信息

Qi Mei-Li, Long Zhaoxuan, Liu Xiao-Cun, Zhang Haijun, Li Jin, Yao Shengkun

机构信息

School of Civil Engineering, Shandong Jiaotong University Ji'nan 250357 China

Jinan Key Laboratory for Low-Carbon and Eco-Friendly Road Materials, Shandong Jiaotong University Ji'nan 250357 China.

出版信息

RSC Adv. 2024 Aug 13;14(35):25369-25377. doi: 10.1039/d4ra04078c. eCollection 2024 Aug 12.

DOI:10.1039/d4ra04078c
PMID:39139250
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11320051/
Abstract

Calcium phosphates (Ca-P) represent a significant class of biological minerals found in natural hard tissues. Crystallization through phase transformation of a metastable precursor is an effective strategy to guide the growth of crystalline Ca-P with exceptional functionality. Despite extensive research on Ca-P, the exact process during the crystallization of amorphous particles to hydroxyapatite (HA) remains elusive. Herein, pure HA microspheres with a core-shell structure are crystallized dissolution and re-crystallization of smooth amorphous calcium phosphate (ACP) microspheres. The transformation is initiated with the increase of the hydrothermal treatment time in the presence of sodium trimetaphosphate and l-glutamic. The underlying mechanisms along with the kinetics of such transformation are explored. Nanocrystalline areas are formed on the smooth ACP microspheres and crystallization advances nanometre-sized clusters formed by directional arrangement of nanocrystalline whiskers. Our findings shed light on a crucial but unclear stage in the genesis of HA crystals, specifically under the conditions of hydrothermal synthesis.

摘要

磷酸钙（Ca-P）是天然硬组织中一类重要的生物矿物质。通过亚稳前驱体的相变进行结晶是引导具有特殊功能的结晶Ca-P生长的有效策略。尽管对Ca-P进行了广泛研究，但无定形颗粒结晶为羟基磷灰石（HA）的确切过程仍不清楚。在此，具有核壳结构的纯HA微球通过光滑无定形磷酸钙（ACP）微球的溶解和再结晶而形成。在三聚偏磷酸钠和L-谷氨酸存在下，随着水热处理时间的增加，转变开始。探索了这种转变的潜在机制及其动力学。光滑的ACP微球上形成纳米晶区域，结晶通过纳米晶须定向排列形成的纳米尺寸簇而推进。我们的研究结果揭示了HA晶体形成过程中一个关键但不清楚的阶段，特别是在水热合成条件下。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e20/11320051/4537ff9a52df/d4ra04078c-f7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e20/11320051/e7bd6b6b61c8/d4ra04078c-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e20/11320051/4537ff9a52df/d4ra04078c-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e20/11320051/005834a874c0/d4ra04078c-f1.jpg
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