甲基对硫磷急性中毒时进行体育锻炼的大鼠的血糖和胰岛素浓度
Blood glucose and insulin concentration in rats subjected to physical exercise in acute poisoning with parathion-methyl.
作者信息
Lukaszewicz-Hussain A, Moniuszko-Jakoniuk J, Pawłowska D
出版信息
Pol J Pharmacol Pharm. 1985 Sep-Oct;37(5):647-51.
Unexercised rats or those subjected to single physical exercise were given parathion-methyl (10 mg/kg p.o. - 0.5 DL50) or oil (vehicle). Blood glucose and serum insulin concentration were assayed 1 h after the treatment. Physical exercise depressed the serum insulin concentration without changes in blood glucose level. In acute poisoning with parathion-methyl hyperglycemia occurred concurrently with hypoinsulinemia. Physical exercise abolished the pesticide-induced hypoinsulinemia, but not hyperglycemia.
未进行运动的大鼠或仅进行单次体育锻炼的大鼠，被给予甲基对硫磷（口服10毫克/千克 - 0.5倍半数致死剂量）或油（赋形剂）。治疗1小时后测定血糖和血清胰岛素浓度。体育锻炼可降低血清胰岛素浓度，而血糖水平无变化。在甲基对硫磷急性中毒时，高血糖与低胰岛素血症同时发生。体育锻炼消除了农药诱导的低胰岛素血症，但未消除高血糖症。
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