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纤维化治疗:全面综述

in fibrosis treatment: a comprehensive review.

作者信息

Liang Qingzhi, Liu Xiaoqin, Peng Xi, Luo Ting, Su Yi, Xu Xin, Xie Hongyan, Gao Hong, Chen Zhengtao, Xie Chunguang

机构信息

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, Sichuan, China.

出版信息

Front Pharmacol. 2024 Jul 30;15:1442181. doi: 10.3389/fphar.2024.1442181. eCollection 2024.

Abstract

Fibrosis is a public health issue of great concern characterized by the excessive deposition of extracellular matrix, leading to the destruction of parenchymal tissue and organ dysfunction that places a heavy burden on the global healthcare system due to its high incidence, disability, and mortality. () has positively affected various human diseases, including fibrosis. In this review, we concentrate on the anti-fibrotic effects of from a molecular perspective while providing information on the safety, adverse effects, and drug interactions of Additionally, we discuss the innovative formulations, which give some references for further investigation and therapeutic use of 's anti-fibrotic qualities. Even with the encouraging preclinical data, additional research is required before relevant clinical trials can be conducted. Therefore, we conclude with recommendations for future studies. It is hoped that this review will provide comprehensive new perspectives on future research and product development related to treatment of fibrosis and promote the efficient development of this field.

摘要

纤维化是一个备受关注的公共卫生问题,其特征是细胞外基质过度沉积,导致实质组织破坏和器官功能障碍,由于其高发病率、致残率和死亡率,给全球医疗系统带来了沉重负担。()已对包括纤维化在内的多种人类疾病产生了积极影响。在本综述中,我们从分子角度关注()的抗纤维化作用,同时提供有关()的安全性、不良反应和药物相互作用的信息。此外,我们还讨论了创新的()制剂,这为进一步研究和治疗性应用()的抗纤维化特性提供了一些参考。即使有令人鼓舞的临床前数据,在进行相关临床试验之前仍需要更多研究。因此,我们最后提出了未来研究的建议。希望本综述能为未来与()治疗纤维化相关的研究和产品开发提供全面的新视角,并推动该领域的高效发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de9d/11319160/f3ca5d1c9ebb/fphar-15-1442181-g001.jpg

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