Merimi Ihssane, Zinoune Lamyae, Aichouni Narjisse, Nasri Siham, Skiker Imane, Bazid Zakaria, Elouafi Noha
Faculty of Medicine and Pharmacy, Mohammed I University, Oujda, Morocco.
Department of Cardiology, Mohammed VI University Hospital/Mohammed I University, Oujda, Morocco.
Radiol Case Rep. 2024 Jul 23;19(10):4237-4241. doi: 10.1016/j.radcr.2024.06.050. eCollection 2024 Oct.
Adenomyosis is a chronic disease associated with abnormal uterine bleeding and debilitating pain with severely reduced quality of life in many affected women. Primary strategies for its management encompass surgical interventions, hormonal therapy, or a synergistic blend of these therapeutic modalities. Dienogest (DNG), a new progestin, is primarily utilized to treat adenomyosis due to its exceptional selectivity for the progesterone receptor. In this uncommon case report, we introduce a 42-year-old woman who experienced hemorrhagic shock as a result of uterine bleeding and pulmonary embolism that occurred while a patient was undergoing dienogest therapy for uterine adenomyosis. This situation necessitated blood transfusion and introduction of drugs then an emergency hysterectomy was scheduled followed by the initiation of anticoagulation. We hypothesize that the emergence of pulmonary embolism was intimately tied to adenomyosis, and the occurrence of hemorrhagic shock was likely due to the intake of dienogest.
子宫腺肌病是一种慢性疾病，与异常子宫出血和使人衰弱的疼痛相关，许多受影响的女性生活质量严重下降。其主要治疗策略包括手术干预、激素治疗或这些治疗方式的协同组合。地诺孕素（DNG）是一种新型孕激素，因其对孕激素受体具有特殊选择性，主要用于治疗子宫腺肌病。在这份罕见的病例报告中，我们介绍了一名42岁的女性，她在接受地诺孕素治疗子宫腺肌病期间，因子宫出血和肺栓塞而发生失血性休克。这种情况需要输血并使用药物，随后安排了急诊子宫切除术，接着开始抗凝治疗。我们推测肺栓塞的出现与子宫腺肌病密切相关，而失血性休克的发生可能是由于服用了地诺孕素。
