Nie Jinhan, Zhang Yi, Ma Jun, Xue Qing, Hu Min, Qi Huichuan
Department of Orthodontics, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Department of Oral Anatomy and Physiology, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Front Psychiatry. 2024 Jul 30;15:1442679. doi: 10.3389/fpsyt.2024.1442679. eCollection 2024.
The association between psychiatric disorders and dentofacial deformities has attracted widespread attention. However, their relationship is currently unclear and controversial.
A two-sample bidirectional MR analysis was performed to study the causal relationship between dentofacial deformity and eight psychiatric disorders, including major depressive disorder, panic disorder, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, Alzheimer's disease, autism spectrum disorder, and neuroticism. Inverse variance weighted, weighted median, MR-Egger regression, weighted mode four methods, and further sensitivity analyses were conducted.
The major depressive disorder affected dentofacial deformity, with an OR = 1.387 (95% CI = 1.181-1.629, = 6.77×10). No other psychiatric disorders were found to be associated with dentofacial deformity. In turn, dentofacial deformity were associated with neuroticism, with an OR = 1.050 (95% CI = 1.008-1.093, = 0.018). And there was no evidence that dentofacial deformity would increase the risk of other psychiatric disorders.
Major depressive disorder might elevate the risk of dentofacial deformities, and dentofacial deformity conditions would increase the risk of the incidence of neuroticism.
精神疾病与牙颌面畸形之间的关联已引起广泛关注。然而，它们之间的关系目前尚不清楚且存在争议。
进行了一项两样本双向孟德尔随机化分析，以研究牙颌面畸形与八种精神疾病之间的因果关系，这八种精神疾病包括重度抑郁症、惊恐障碍、精神分裂症、双相情感障碍、注意力缺陷多动障碍、阿尔茨海默病、自闭症谱系障碍和神经质。采用逆方差加权、加权中位数、孟德尔随机化-Egger回归、加权模式四种方法，并进行了进一步的敏感性分析。
重度抑郁症影响牙颌面畸形，优势比（OR）=1.387（95%置信区间[CI]=1.181-1.629，P=6.77×10⁻⁴）。未发现其他精神疾病与牙颌面畸形有关。反过来，牙颌面畸形与神经质有关，OR=1.050（95%CI=1.008-1.093，P=0.018）。并且没有证据表明牙颌面畸形会增加其他精神疾病的风险。
重度抑郁症可能会增加牙颌面畸形的风险，而牙颌面畸形状况会增加神经质发病的风险。
