Sengupta Simon, Krieck Sven, Westerhausen Matthias
Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University Jena, Humboldtstraße 8, D-07743 Jena, Germany.
Dalton Trans. 2024 Sep 18;53(36):14961-14965. doi: 10.1039/d4dt02035a.
Organocalcium compounds are highly reactive reagents whereas the alkaline-earth metal itself is a weak reductant. This discrepancy hampered a straightforward development of an organocalcium chemistry. The generation of the highly reactive organocalcium reagent and immediate metalation of a H-acidic compound (iGMM) or addition onto a polar π-system (iGAM) offers not only a loophole to organocalcium reagents but opens the entry to a rich organic chemistry of this non-toxic and globally abundant alkaline-earth metal, being competitive to the organolithium chemistry.
有机钙化合物是高活性试剂，而碱土金属本身是一种弱还原剂。这种差异阻碍了有机钙化学的直接发展。高活性有机钙试剂的生成以及H-酸性化合物的直接金属化（iGMM）或加成到极性π-体系上（iGAM）不仅为有机钙试剂提供了一个突破口，还开启了这种无毒且全球储量丰富的碱土金属丰富有机化学的大门，可与有机锂化学相竞争。
