Atıcı Aytuğ, Kanık Arzu, Çelik Yalçın, Helvacı İlter
Division of Neonatology, Department of Pediatrics, Mersin University School of Medicine, Mersin, Türkiye.
Department of Biostatistics and Medical Informatics, Mersin University School of Medicine, Mersin, Türkiye.
Turk Arch Pediatr. 2024 May 2;59(3):270-276. doi: 10.5152/TurkArchPediatr.2024.23313.
Fetal growth is known to be affected by ethnic and environmental factors; therefore, intrauterine growth references for each community vary and need to be determined individually. This study aimed to construct intrauterine growth references for Turkish infants. This prospective, multicenter, cross-sectional study was performed in collaboration with the Turkish Ministry of Health and the Turkish Neonatology Society, in coordination with Mersin University. The study included 33 healthcare centers from all regions of Türkiye. The study included singleton infants who were born alive at 24-42 weeks of gestation. Weight, length, and head circumference were measured within the first 4 hours of delivery. The Lambda-Mu-Sigma method and penalized likelihood were used to establish the curves and construct percentiles. In all, data from 10 286 infants were analyzed and 552 cases that did not meet the inclusion criteria were excluded. The intrauterine growth curves and tables for Turkish infants were constructed using the data for 9734 singleton infants born at 24-42 weeks of gestation. To the best of our knowledge this is the first study to establish intrauterine growth references for Turkish infants, based on a cohort of infants from all regions of Türkiye. Using these new references, the intrauterine growth of Turkish infants and postnatal growth of those born prematurely can be followed-up more effectively, and it will be possible to more accurately determine if Turkish infants are small for gestational age or large for gestational age.
已知胎儿生长受种族和环境因素影响；因此，每个群体的子宫内生长参考值各不相同，需要单独确定。本研究旨在构建土耳其婴儿的子宫内生长参考值。这项前瞻性、多中心横断面研究是与土耳其卫生部和土耳其新生儿学会合作，并在梅尔辛大学的协调下进行的。该研究纳入了来自土耳其所有地区的33个医疗中心。研究对象为妊娠24 - 42周出生的单胎活产婴儿。在出生后的前4小时内测量体重、身长和头围。使用Lambda - Mu - Sigma方法和惩罚似然法来建立曲线并构建百分位数。总共分析了10286例婴儿的数据，排除了552例不符合纳入标准的病例。利用9734例妊娠24 - 42周出生的单胎婴儿的数据构建了土耳其婴儿的子宫内生长曲线和表格。据我们所知，这是第一项基于来自土耳其所有地区的婴儿队列建立土耳其婴儿子宫内生长参考值的研究。使用这些新的参考值，可以更有效地跟踪土耳其婴儿的子宫内生长情况以及早产婴儿的出生后生长情况，并且能够更准确地确定土耳其婴儿是小于胎龄儿还是大于胎龄儿。
