Joint Programme of Nanchang University and Queen Mary University of London, Nanchang University, Nanchang, China.
Queen Mary School, Nanchang University, Nanchang, China.
Int Ophthalmol. 2024 Aug 14;44(1):348. doi: 10.1007/s10792-024-03266-8.
This study aimed to investigate the association between the CC-cytokine ligand-2 (CCL2) 2518A/G (rs1024611) single nucleotide polymorphism (SNP) and susceptibility to age-related macular degeneration (AMD).
PubMed, Embase, Web of Science, and other databases were searched for articles published before August 24, 2023. After searching, data extraction, and quality assessment, meta-analysis and trial sequential analysis were conducted using RevMan 5.4, Stata 17.0, and TSA 0.9.5.10 Beta software. Combined OR, P values, and 95% confidence intervals (CIs) were calculated. Sensitivity analysis, subgroup analysis and publication bias assessment were also performed.
Six articles, comprising 1186 cases and 1124 controls, were included. No significant statistical difference was found in six main outcomes. However, due to observed heterogeneity and high sensitivity, subgroup analysis was performed, revealing statistically significant differences across different regions. No significant publication bias was observed. Trial sequential analysis suggested the need for additional follow-up case-control studies to further validate the findings.
The CCL2 gene 2518A/G (rs1024611) polymorphism is associated with AMD susceptibility. Among Caucasian populations in West Asia and Europe, the G allele is protective against AMD, whereas in East and South Asia, it poses a risk factor.
本研究旨在探讨 CC-细胞因子配体-2（CCL2）2518A/G（rs1024611）单核苷酸多态性（SNP）与年龄相关性黄斑变性（AMD）易感性之间的关联。
检索了PubMed、Embase、Web of Science 等数据库，检索时间截至 2023 年 8 月 24 日。检索后进行数据提取和质量评估，使用 RevMan 5.4、Stata 17.0 和 TSA 0.9.5.10 Beta 软件进行荟萃分析和试验序贯分析。计算合并 OR、P 值和 95%置信区间（CI）。还进行了敏感性分析、亚组分析和发表偏倚评估。
纳入了 6 篇文章，包括 1186 例病例和 1124 例对照。在六个主要结局中未发现显著的统计学差异。然而，由于观察到的异质性和高敏感性，进行了亚组分析，结果显示不同地区存在统计学差异。未观察到显著的发表偏倚。试验序贯分析表明需要进行更多的随访病例对照研究来进一步验证研究结果。
CCL2 基因 2518A/G（rs1024611）多态性与 AMD 易感性相关。在西亚和欧洲的白种人群中，G 等位基因对 AMD 具有保护作用，而在东亚和南亚，它则是一个危险因素。
