Rural Technology and Health Center, Federal University of Campina Grande, Patos, PB, Brazil.
Faculty of Dentistry, Post-Graduate Program in Dentistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.
Clin Oral Investig. 2024 Aug 14;28(9):485. doi: 10.1007/s00784-024-05876-z.
This study analyzed, using an umbrella review, existing systematic reviews on medications to prevent and control postoperative endodontic pain to guide professionals in choosing the most effective drug.
An electronic search in the PubMed (MEDLINE), LILACS, SciELO, EMBASE, Scopus, Web of Science, Cochrane Reviews, and Data Archiving and Networked Services (DANS) databases retrieved 17 systematic reviews. The study included only systematic reviews of clinical trials with or without meta-analyses evaluating effectiveness of medications in reducing pain after non-surgical endodontic treatment.
The evidence showed that steroidal and non-steroidal anti-inflammatory drugs and opioids effectively controlled pain within six to 24 h.
Dexamethasone, prednisolone, paracetamol, and mainly ibuprofen provided higher postoperative pain relief. The quality of evidence of the reviews ranged from very low to high, and the risk of bias from low to high, suggesting the need for well-designed clinical trials to provide confirmatory evidence.
This review emphasizes the efficacy of developing protocols for pain control after endodontic therapy.
本研究通过伞式综述分析了预防和控制根管治疗术后疼痛的药物的现有系统评价，以指导专业人员选择最有效的药物。
通过电子检索 PubMed（MEDLINE）、LILACS、SciELO、EMBASE、Scopus、Web of Science、Cochrane Reviews 和 Data Archiving and Networked Services（DANS）数据库，共检索到 17 篇系统评价。本研究仅纳入了评估非手术根管治疗后药物减轻疼痛效果的临床试验的系统评价，无论是否进行了荟萃分析。
证据表明，甾体和非甾体抗炎药以及阿片类药物在 6 至 24 小时内有效控制疼痛。
地塞米松、泼尼松龙、对乙酰氨基酚，主要是布洛芬，能更好地缓解术后疼痛。评价的证据质量从极低到高，偏倚风险从低到高，这表明需要精心设计临床试验来提供确证性证据。
本综述强调了制定根管治疗后疼痛控制方案的有效性。
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