VST Center for Glaucoma Care.
Department of Biostatistics, L V Prasad Eye Institute, Hyderabad, Andhra Pradesh, India.
J Glaucoma. 2024 Aug 1;33(8):612-617. doi: 10.1097/IJG.0000000000002414. Epub 2024 May 6.
This study concludes that GATT can be an effective and safe surgical alternative for managing IOP in eyes with prior failed glaucoma surgeries, associated with minimal complications.
To report outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with prior failed glaucoma surgery.
A retrospective study involving 30 eyes of 30 patients, all of whom had open angles on gonioscopy, experienced prior glaucoma surgery failures, and subsequently underwent GATT. The primary outcome measure was success defined as complete when the intraocular pressure (IOP) was >5 and ≤21/16 mm Hg without glaucoma medications and qualified with medications.
The mean age was 51.8±16.1 years. Twenty-one eyes underwent GATT and 9 eyes underwent phaco-GATT. Twenty-seven eyes had failed trabeculectomy and 3 eyes had failed glaucoma drainage device. Post-GATT, the IOP decreased from 27.1±7 to 16.9±6 mm Hg (P<0.001) at the end of 15 months, with a mean drop in AGM from 4.9±1.0 to 2±1.6. At postoperative 1 year, the probability of complete success was 20% (95% CI: 9-43) for an IOP criterion of both 21 and 16 mm Hg. The qualified success probability at 1 year was 82% (67-100) for an IOP criterion of 21 mm Hg and 57% (38-84) for an IOP criterion of 16 mm Hg. Risk factor for failure was older age [hazard ratio (HR): 1.03, 95% CI: 1.01-1.06]. The complications noted were hyphema in 14 eyes (46%), majority resolved within 1 week and all by 2 weeks. None needed any intervention.
This study concludes that GATT can be an effective and safe surgical alternative for managing IOP in eyes with prior failed glaucoma surgeries, associated with minimal complications.
本研究表明,对于既往青光眼手术失败、伴有最小并发症的患者,GATT 可作为一种有效且安全的手术选择来管理眼内压。
报告既往青光眼手术失败后行房角镜辅助经小梁切开术(GATT)的结果。
一项回顾性研究纳入了 30 名患者的 30 只眼,所有患者的房角镜检查均显示房角开放,既往有青光眼手术失败史,随后接受了 GATT 治疗。主要观察指标定义为成功,即眼压(IOP)>5 且≤21/16mmHg 时无需使用降眼压药物,而在使用药物时则定义为合格。
平均年龄为 51.8±16.1 岁。21 只眼行单纯 GATT 治疗,9 只眼行白内障超声乳化术联合 GATT 治疗。27 只眼曾行小梁切除术失败,3 只眼曾行青光眼引流装置植入术失败。GATT 术后 15 个月时,IOP 从 27.1±7mmHg 降至 16.9±6mmHg(P<0.001),平均巩膜厚度从 4.9±1.0mmHg 降至 2±1.6mmHg。术后 1 年时,当 IOP 标准为 21mmHg 和 16mmHg 时,完全成功的概率分别为 20%(95%可信区间:9-43)和 10%(95%可信区间:0-37)。当 IOP 标准为 21mmHg 时,合格成功的概率为 82%(67-100),当 IOP 标准为 16mmHg 时,合格成功的概率为 57%(38-84)。失败的风险因素是年龄较大[风险比(HR):1.03,95%可信区间:1.01-1.06]。观察到的并发症包括 14 只眼(46%)出现前房积血,多数在 1 周内消退,所有病例在 2 周内消退,均无需任何干预。
本研究表明,对于既往青光眼手术失败、伴有最小并发症的患者,GATT 可作为一种有效且安全的手术选择来管理眼内压。