Division of Paediatric Hematology-Oncology, University of Bari, Bari.
Division of Paediatric Hematology-Oncology, University of Padova, Padova, Italy.
J Pediatr Hematol Oncol. 2024 Oct 1;46(7):373-374. doi: 10.1097/MPH.0000000000002930. Epub 2024 Aug 12.
RMS is a malignant tumor of soft tissues affecting primarily children and adolescents. Around 6% to 23% RMS patients present bone marrow infiltration but leukemia-like involvement is very rare; in these patients cytomorphology on bone marrow smears can lead to misdiagnosis. Differential diagnosis with alveolar RMS should be kept in mind in every pediatric patient presenting with a marked bone marrow involvement in the absence of typical lymphoproliferative findings.
横纹肌肉瘤是一种软组织恶性肿瘤,主要影响儿童和青少年。约 6%至 23%的横纹肌肉瘤患者有骨髓浸润,但类似白血病的累及非常罕见;在这些患者中,骨髓涂片的细胞形态学可能导致误诊。在没有典型淋巴增生表现的情况下,每一个出现明显骨髓累及的儿科患者都应考虑与肺泡横纹肌肉瘤进行鉴别诊断。