Vrije Universiteit Brussel (VUB), Universitair ziekenhuis Brussel (UZB), Belgium; Université Libre de Bruxelles (ULB).
Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium.
Top Antivir Med. 2024 Apr 18;32(2):437-444.
Limited therapeutic options are available for patients with multidrug-resistant HIV. This report describes a 38-year-old female who was perinatally infected with HIV-1 and treated with 14 different antiretroviral regimens over 27 years, gradually leading to 4-class drug resistance. Despite various attempts to obtain sustained viral suppression, including the off-label administration of intravenous foscarnet and enfuvirtide, and thorough follow-up with 16 viral genotyping/phenotyping from 1999 to 2021, viral control was not maintained. Recently, the introduction of a regimen with fostemsavir and lenacapavir resulted in long-term viral suppression.
对于多重耐药性 HIV 患者，治疗选择有限。本报告描述了一位 38 岁女性，她在围产期感染了 HIV-1，并在 27 年中接受了 14 种不同的抗逆转录病毒治疗方案，逐渐导致了 4 类药物耐药。尽管进行了各种尝试以获得持续的病毒抑制，包括使用非标签药物静脉注射膦甲酸和恩夫韦肽，以及从 1999 年到 2021 年进行了 16 次病毒基因分型/表型的彻底随访，但未能维持病毒控制。最近，引入 fostemsavir 和 lenacapavir 的治疗方案导致了长期的病毒抑制。
