Nutrilite Health Institute, Shanghai, China.
Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Clin Nutr. 2024 Sep;43(9):2177-2185. doi: 10.1016/j.clnu.2024.07.037. Epub 2024 Aug 6.
BACKGROUND & AIMS: Skeletal muscle is an important contributor to joint health. Previous studies have shown that age-related muscle mass and strength loss are closely associated with the development of knee osteoarthritis. The objective of this study is to investigate whether a high plant protein/peptide nutrition supplementation can alleviate knee osteoarthritis by improving muscle mass and strength.
This randomized, double-blind, placebo-controlled trial that included participants aged 50-70 years diagnosed with knee osteoarthritis and sarcopenia was conducted in China from February 2022 to September 2022 (ChiCTR2200056415). Participants were randomly assigned to receive either a 12-week high plant protein/peptide nutrition supplementation or a placebo twice daily, with one serving each after breakfast and dinner, respectively. The primary outcome analyzed using intention-to-treat analysis was difference in Short Physical Performance Battery (SPPB) from baseline to week 12 between the two groups. The secondary outcomes included changes in muscle mass, strength, symptom and imaging of knee osteoarthritis, body composition, biochemical parameters, and health quality scores.
After 12 weeks, a total of 124 participants (38.7% male) completed the trial and were included in the final analysis. Over the 12-week follow-up, the experimental group showed a significant improvement in the SPPB total score (1.03, 95% CI, 0.69 to 1.38, P < 0.0001) compared with the placebo group. Grip strength (2.83 kg, 95% CI, 2.13 to 3.53, P < 0.0001) and skeletal muscle mass index (0.66 kg/m, 95% CI, 0.45 to 0.86, P < 0.0001) were also significantly increased in the experimental group relative to the placebo group. The mean change in Western Ontario and McMaster Universities Osteoarthritis Index total score was -3.95 points (95% CI, -5.02 to -2.89, P < 0.0001) in the experimental group and 0.23 points (95% CI, -0.17 to 0.63, P = 0.253) in the placebo group. Additionally, within the experimental group, nine participants experienced an improvement in osteophyte magnetic resonance imaging results, while no improvement was observed in the placebo group. The experimental group also exhibited significant improvements in health quality compared with the placebo group as assessed by Short Form 36, the World Health Organization Quality of Life Brief Scale, and the Chalder Fatigue Scale. No serious adverse events were reported during the trial.
Oral supplementation with high levels of plant protein/peptides can alleviate symptoms of osteoarthritis in elderly individuals with minor or mild knee osteoarthritis and sarcopenia. This improvement may be attributed to the enhancements of muscle mass, strength, and physical performance.
骨骼肌是关节健康的重要贡献者。先前的研究表明，与年龄相关的肌肉质量和力量损失与膝骨关节炎的发展密切相关。本研究旨在探讨高植物蛋白/肽营养补充剂是否可以通过增加肌肉质量和力量来缓解膝骨关节炎。
这是一项在中国进行的随机、双盲、安慰剂对照试验，纳入了年龄在 50-70 岁之间、被诊断为膝骨关节炎和肌肉减少症的患者。参与者被随机分配接受 12 周的高植物蛋白/肽营养补充剂或安慰剂，每天两次，分别在早餐和晚餐后服用一次。主要结局分析采用意向治疗分析，比较两组从基线到第 12 周的短体物理表现电池（SPPB）评分差异。次要结局包括肌肉质量、力量、膝骨关节炎的症状和影像学变化、身体成分、生化参数和健康质量评分的变化。
经过 12 周的随访，共有 124 名参与者（38.7%为男性）完成了试验并纳入最终分析。在 12 周的随访中，实验组的 SPPB 总分（1.03，95%CI，0.69 至 1.38，P<0.0001）与安慰剂组相比显著提高。握力（2.83kg，95%CI，2.13 至 3.53，P<0.0001）和骨骼肌质量指数（0.66kg/m，95%CI，0.45 至 0.86，P<0.0001）也显著增加实验组与安慰剂组相比。实验组的西部安大略省和麦克马斯特大学骨关节炎指数总分的平均变化为-3.95 分（95%CI，-5.02 至-2.89，P<0.0001），安慰剂组为 0.23 分（95%CI，-0.17 至 0.63，P=0.253）。此外，在实验组中，有 9 名参与者的骨赘磁共振成像结果得到改善，而安慰剂组没有改善。实验组的健康质量也明显优于安慰剂组，通过 36 项简短健康调查问卷、世界卫生组织生活质量简要量表和 Chalder 疲劳量表进行评估。试验期间未报告严重不良事件。
口服高植物蛋白/肽可缓解老年轻度或中度膝骨关节炎和肌肉减少症患者的骨关节炎症状。这种改善可能归因于肌肉质量、力量和身体表现的增强。
