早期神经元抑制塑造了成年大脑皮质的半球间连接。

Early neuronal inhibition sculpts adult cortical interhemispheric connectivity.

机构信息

Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège 4000, Belgium.

Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège 4000, Belgium; WELBIO department, WEL Research Institute, Avenue Pasteur, 6, 1300 Wavre, Belgium.

出版信息

Trends Neurosci. 2024 Sep;47(9):667-668. doi: 10.1016/j.tins.2024.08.002. Epub 2024 Aug 13.

DOI:10.1016/j.tins.2024.08.002

PMID:39142912

Abstract

The maturation of cerebral cortical networks during early life involves a major reorganization of long-range axonal connections. In a recent study, Bragg-Gonzalo, Aguilera, et al. discovered that in mice, the interhemispheric connections sent by S1L4 callosal projection neurons are pruned via the tight control of their ipsilateral synaptic integration, which relies on the early activity of specific interneurons.

摘要

大脑皮质网络在生命早期的成熟过程涉及长程轴突连接的主要重组。在最近的一项研究中，Bragg-Gonzalo、Aguilera 等人发现，在小鼠中，S1L4 胼胝体投射神经元发出的半球间连接通过其同侧突触整合的紧密控制被修剪，这依赖于特定中间神经元的早期活动。