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在Plan2Heat中对相控阵加热系统实施情况的验证。

Validation of the implementation of phased-array heating systems in Plan2Heat.

作者信息

Kok H P, Crezee J

机构信息

Amsterdam UMC, University of Amsterdam, Dept. Radiation Oncology, Cancer Center Amsterdam, Meibergdreef 9, 1105, AZ Amsterdam, The Netherlands.

Cancer Center Amsterdam, Treatment and quality of life, Cancer biology and immunology, Amsterdam, The Netherlands.

出版信息

Strahlenther Onkol. 2025 Feb;201(2):135-150. doi: 10.1007/s00066-024-02264-0. Epub 2024 Aug 14.

DOI:10.1007/s00066-024-02264-0
PMID:39143400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11754364/
Abstract

BACKGROUND

Hyperthermia treatment planning can be supportive to ensure treatment quality, provided reliable prediction of the heating characteristics (i.e., focus size and effects of phase-amplitude and frequency steering) of the device concerned is possible. This study validates the predictions made by the treatment planning system Plan2Heat for various clinically used phased-array systems.

METHODS

The evaluated heating systems were AMC-2, AMC-4/ALBA-4D (Med-Logix srl, Rome, Italy), BSD Sigma-30, and Sigma-60 (Pyrexar Medical, Salt Lake City, UT, USA). Plan2Heat was used for specific absorption rate (SAR) simulations in phantoms representing measurement set-ups reported in the literature. SAR profiles from published measurement data based on E‑field or temperature rise were used to compare the device-specific heating characteristics predicted by Plan2Heat.

RESULTS

Plan2Heat is able to predict the correct location and size of the SAR focus, as determined by phase-amplitude settings and operating frequency. Measured effects of phase-amplitude steering on focus shifts (i.e., local SAR minima or maxima) were also correctly reflected in treatment planning predictions. Deviations between measurements and simulations were typically < 10-20%, which is within the range of experimental uncertainty for such phased-array measurements.

CONCLUSION

Plan2Heat is capable of adequately predicting the heating characteristics of the AMC‑2, AMC-4/ALBA-4D, BSD Sigma-30, and Sigma-60 phased-array systems routinely used in clinical hyperthermia.

摘要

背景

如果能够可靠地预测相关设备的加热特性（即焦点尺寸以及相位 - 幅度和频率控制的效果），热疗治疗计划有助于确保治疗质量。本研究验证了治疗计划系统Plan2Heat对各种临床使用的相控阵系统所做预测的准确性。

方法

评估的加热系统有AMC - 2、AMC - 4/ALBA - 4D（意大利罗马的Med - Logix srl公司）、BSD Sigma - 30和Sigma - 60（美国犹他州盐湖城的Pyrexar Medical公司）。Plan2Heat用于在代表文献中报道的测量设置的体模中进行比吸收率（SAR）模拟。基于电场或温度升高的已发表测量数据的SAR分布图用于比较Plan2Heat预测的特定设备加热特性。

结果

Plan2Heat能够根据相位 - 幅度设置和工作频率预测SAR焦点的正确位置和大小。相位 - 幅度控制对焦点偏移（即局部SAR最小值或最大值）的测量效果在治疗计划预测中也得到了正确反映。测量值与模拟值之间的偏差通常<10 - 20%，这在此类相控阵测量的实验不确定度范围内。

结论

Plan2Heat能够充分预测临床热疗中常规使用的AMC - 2、AMC - 4/ALBA - 4D、BSD Sigma - 30和Sigma - 60相控阵系统的加热特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/29521bec1f6e/66_2024_2264_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/aa058e97fb2d/66_2024_2264_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/0986becf9122/66_2024_2264_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/3ce87b279654/66_2024_2264_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/7a43999c3992/66_2024_2264_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/752081527822/66_2024_2264_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/78d7036c84ba/66_2024_2264_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/00209e6dbbf7/66_2024_2264_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/29521bec1f6e/66_2024_2264_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/aa058e97fb2d/66_2024_2264_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/0986becf9122/66_2024_2264_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/3ce87b279654/66_2024_2264_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/7a43999c3992/66_2024_2264_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/752081527822/66_2024_2264_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/78d7036c84ba/66_2024_2264_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/00209e6dbbf7/66_2024_2264_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ac/11754364/29521bec1f6e/66_2024_2264_Fig8_HTML.jpg

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Comput Methods Programs Biomed. 2023 Oct;240:107675. doi: 10.1016/j.cmpb.2023.107675. Epub 2023 Jun 10.
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Field and Temperature Shaping for Microwave Hyperthermia: Recent Treatment Planning Tools to Enhance SAR-Based Procedures.微波热疗的场与温度塑形：用于增强基于比吸收率（SAR）程序的最新治疗计划工具
Cancers (Basel). 2023 Mar 2;15(5):1560. doi: 10.3390/cancers15051560.
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Adapt2Heat: treatment planning-assisted locoregional hyperthermia by on-line visualization, optimization and re-optimization of SAR and temperature distributions.Adapt2Heat：通过在线可视化、SAR 和温度分布的优化和重新优化，实现治疗计划辅助的局部热疗。
Int J Hyperthermia. 2022;39(1):265-277. doi: 10.1080/02656736.2022.2032845.
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