Amsterdam UMC Location University of Amsterdam, Radiation Oncology, Amsterdam, The Netherlands.
Cancer Center Amsterdam, Treatment and Quality of Life, Cancer Biology and Immunology, Amsterdam, The Netherlands.
Int J Hyperthermia. 2022;39(1):952-966. doi: 10.1080/02656736.2022.2093996.
Capacitive devices are used for hyperthermia delivery, initially mainly in Asia, but nowadays also increasingly in Europe. Treatment planning can be very useful to determine the most effective patient-specific treatment set-up. This paper provides a validation of GPU-based simulations using Plan2Heat for capacitive hyperthermia devices.
Validation was first performed by comparing simulations with an analytical solution for a spherical object placed inside a uniform electric field. Resolution was 5, 2.5 or 1 mm. Next, simulations for homogeneous and inhomogeneous phantom setups were performed for Thermotron RF8 and Celsius TCS capacitive heating devices at 2.5 mm resolution. Also different combinations of electrode sizes were evaluated. Normalized SAR profiles were compared to phantom measurements from the literature. Possible clinical use of treatment planning was demonstrated for an anal cancer patient, evaluating different treatment set-ups in prone and supine position.
Numerical and analytical solutions showed excellent agreement. At the center of the sphere, the error was 5.1%, 2.9% and 0.2% for a resolution of 5, 2.5 and 1 mm, respectively. Comparison of measurements and simulations for both Thermotron RF8 and Celsius TCS showed very good agreement within 5% for all phantom set-ups. Simulations were capable of accurately predicting the penetration depth; a very relevant parameter for clinical application. The patient case illustrated that planning can provide insight by comparing effectiveness of different treatment strategies.
Plan2Heat can rapidly and accurately predict heating patterns generated by capacitive devices. Thus, Plan2Heat is suitable for patient-specific treatment planning for capacitive hyperthermia.
电容式设备用于热疗输送，最初主要在亚洲使用，但现在在欧洲也越来越多地使用。治疗计划对于确定最有效的针对患者的治疗方案非常有用。本文使用 Plan2Heat 对电容式热疗设备进行了基于 GPU 的模拟验证。
首先通过将模拟结果与放置在均匀电场中的球形物体的解析解进行比较来进行验证。分辨率为 5、2.5 或 1mm。接下来，在 2.5mm 的分辨率下，针对 Thermotron RF8 和 Celsius TCS 电容加热设备的均匀和不均匀模型进行了模拟。还评估了不同电极尺寸的组合。将归一化 SAR 曲线与文献中的体模测量结果进行了比较。通过评估不同的治疗方案，演示了对一位肛门癌患者进行治疗计划的可能临床应用，患者分别处于俯卧位和仰卧位。
数值和解析解的结果非常吻合。在球体中心，分辨率为 5、2.5 和 1mm 时，误差分别为 5.1%、2.9%和 0.2%。Thermotron RF8 和 Celsius TCS 的测量值与模拟值的比较显示，对于所有模型设置，在 5%以内都有非常好的一致性。模拟能够准确预测穿透深度；这是临床应用的一个非常重要的参数。患者案例表明，通过比较不同治疗策略的有效性，计划可以提供深入的了解。
Plan2Heat 可以快速准确地预测电容式设备产生的加热模式。因此，Plan2Heat 适用于电容式热疗的患者特定治疗计划。
