FTO 基因多态性与多囊卵巢综合征易感性的关系：一项荟萃分析。
FTO gene polymorphism and susceptibility to polycystic ovary syndrome: A meta-analysis.
机构信息
Department of Gynecology, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, China.
Department of Gynecology and Obstetrics, Yiwu Central Hospital, Yiwu, China.
出版信息
J Obstet Gynaecol Res. 2024 Sep;50(9):1703-1712. doi: 10.1111/jog.16047. Epub 2024 Aug 14.
AIM
To explore the correlation between Fat mass and objectivity associated gene (FTO) rs9939609 polymorphism and susceptibility to polycystic ovary syndrome.
METHODS
Case-control studies on the relationship between FTO rs9939609 A/T polymorphism and PCOS were searched in PubMed, EMBASE, and Web of Science according to inclusion and exclusion criteria. STATA 12.0 software was conducted for Meta-analysis.
RESULTS
Nine case-control studies were included, including 1410 cases in PCOS group and 1223 cases in healthy control group. The results of meta-analysis showed that FTO rs9939609 gene polymorphism was associated with PCOS susceptibility, and the risk of developing PCOS was 1.19 times higher for T alleles carriers than for A alleles carriers, and some similar associations were observed in Asian populations.
CONCLUSIONS
In summary, FTO rs9939609 gene polymorphism is significantly associated with PCOS susceptibility, especially in Asian populations.
目的
探讨脂肪质量和肥胖相关基因（FTO）rs9939609 多态性与多囊卵巢综合征易感性的相关性。
方法
根据纳入和排除标准，在 PubMed、EMBASE 和 Web of Science 中搜索关于 FTO rs9939609 A/T 多态性与 PCOS 关系的病例对照研究。采用 STATA 12.0 软件进行 Meta 分析。
结果
共纳入 9 项病例对照研究，包括 PCOS 组 1410 例，健康对照组 1223 例。Meta 分析结果表明，FTO rs9939609 基因多态性与 PCOS 易感性相关，T 等位基因携带者发生 PCOS 的风险是 A 等位基因携带者的 1.19 倍，在亚洲人群中也观察到了类似的关联。
结论
综上所述，FTO rs9939609 基因多态性与 PCOS 易感性显著相关，尤其是在亚洲人群中。
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