Halliday Bradley, Chatfield Sarah, Hosking Joanne, Freeman Jennifer
Faculty of Health University of Plymouth Plymouth UK.
Peninsula Clinical Trials Unit Plymouth UK.
Health Sci Rep. 2024 Aug 13;7(8):e2308. doi: 10.1002/hsr2.2308. eCollection 2024 Aug.
Pregnancy-related pelvic girdle pain (PPGP) is estimated to affect between 20% and 70% of pregnant women with 10% experiencing it for more than 3 months postpartum. Women may also experience depression during this period. Understanding the prevalence of depression in women with PPGP is important to inform clinical management. This systematic review aimed to examine the prevalence of depression in women with PPGP in the antepartum and postpartum periods.
A systematic review and meta-analysis. Seven databases were searched from inception until May 24, 2023, combining keywords relating to pelvic girdle pain (PGP), depression, and pregnancy. Two investigators independently screened study titles and abstracts against the eligibility criteria, extracting data characteristics of all included studies. Included articles were assessed for risk of bias. Summary estimates of the prevalence of depression were calculated with a random effects meta-analysis (stratified by antepartum and postpartum periods).
Eleven studies (3172 participants) were included with nine suitable for meta-analysis. The overall summary estimate of prevalence of depression among women with PPGP was 24% (95% confidence interval [CI] = 15%-37%), with significant heterogeneity between studies ( = 97%, < 0.01). Among individual studies, the estimates ranged from 18% to 48% in the antepartum PGP population and from 5% to 39% in the postpartum PGP population. The summary estimate in the antepartum group was 37% (95% CI = 19%-59%; prediction interval 8%-81%) and 15% (95% CI = 7%-30%; prediction interval 3%-56%) in the postpartum group, although time (antepartum vs. postpartum) did not have a statistically significant moderating effect ( = 0.06). Two thirds of the studies were undertaken with Scandinavian populations, limiting the generalizability of these findings.
Summary estimates for the prevalence of depression in women with PPGP are similar to previous studies investigating depression in the general peri-natal population.
据估计，妊娠相关骨盆带疼痛（PPGP）影响20%至70%的孕妇，其中10%在产后3个月以上仍受其影响。在此期间，女性也可能会出现抑郁。了解PPGP女性中抑郁症的患病率对于指导临床管理很重要。本系统评价旨在研究产前和产后PPGP女性中抑郁症的患病率。
进行系统评价和荟萃分析。检索了7个数据库，从建库至2023年5月24日，结合与骨盆带疼痛（PGP）、抑郁症和妊娠相关的关键词。两名研究者根据纳入标准独立筛选研究标题和摘要，提取所有纳入研究的数据特征。对纳入的文章进行偏倚风险评估。采用随机效应荟萃分析（按产前和产后阶段分层）计算抑郁症患病率的汇总估计值。
纳入了11项研究（3172名参与者），其中9项适合进行荟萃分析。PPGP女性中抑郁症患病率的总体汇总估计值为24%（95%置信区间[CI]=15%-37%），研究之间存在显著异质性（ =97%， <0.01）。在个别研究中，产前PGP人群的估计值范围为18%至48%，产后PGP人群的估计值范围为5%至39%。产前组的汇总估计值为37%（95%CI=19%-59%；预测区间8%-81%），产后组为15%（95%CI=7%-30%；预测区间3%-56%），尽管时间（产前与产后）没有统计学上的显著调节作用（ =0.06）。三分之二的研究是针对斯堪的纳维亚人群进行的，限制了这些结果的普遍性。
PPGP女性中抑郁症患病率的汇总估计值与先前调查围产期一般人群抑郁症的研究结果相似。
