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氨甲环酸治疗86岁患者慢性硬膜下血肿的病例报告

A Case Report of Tranexamic Acid for the Treatment of Chronic Subdural Hematoma in an 86-Year-Old Patient.

作者信息

Gharaibeh Shatha, Shurman Abdallah, Gharaibeh Abeer, Torcuator Roy

机构信息

Center for Cognition and Neuroethics, University of Michigan-Flint, Flint, USA.

Clinical Research, Insight Research Institute, Flint, USA.

出版信息

Cureus. 2024 Aug 14;16(8):e66846. doi: 10.7759/cureus.66846. eCollection 2024 Aug.

Abstract

Fibrinolytic and coagulative hyperactivity is proven to have a role in liquefaction and progression of chronic subdural hematoma (CSDH). Tranexamic acid was one of the pharmaceutical options that was explored, as it inhibits the hyper-fibrinolytic activity and reduces the vascular permeability in CSDH, leading to a gradual resolution of the hematoma. In this case study, we present a case of using tranexamic acid for CSDH treatment in an 86-year-old patient with co-morbidities. The complete resolution of the hematoma following using tranexamic acid in this case with no history of recurrence in two years follow-up supports its efficacy in CSDH treatment and may be considered as one of the strategies that help prevent surgeries.

摘要

纤维蛋白溶解和凝血功能亢进被证明在慢性硬膜下血肿(CSDH)的液化和进展中起作用。氨甲环酸是探索的药物选择之一,因为它抑制CSDH中的高纤维蛋白溶解活性并降低血管通透性,从而导致血肿逐渐消退。在本病例研究中,我们展示了一例在一名患有多种合并症的86岁患者中使用氨甲环酸治疗CSDH的病例。该病例使用氨甲环酸后血肿完全消退,在两年随访中无复发史,这支持了其在CSDH治疗中的疗效,并且可被视为有助于避免手术的策略之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f084/11323430/eec96f1d08ad/cureus-0016-00000066846-i01.jpg

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