Bombaci Bruno, Passanisi Stefano, Lombardo Fortunato, Salzano Giuseppina
Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Messina, Italy.
Transl Pediatr. 2024 Jul 31;13(7):1231-1241. doi: 10.21037/tp-24-114. Epub 2024 Jul 16.
In recent years, there has been growing interest in glycemic variability within the scientific community, particularly regarding its potential as an independent risk factor for diabetes-related long-term complications. This narrative review aimed to provide a comprehensive overview of short-term glycemic variability in children and adolescents with type 1 diabetes (T1D).
We performed a search of published literature on the PubMed MEDLINE database using the following combination of search terms: "glycemic variability", "pediatric", "type 1 diabetes", and "children".
The widespread use of continuous glucose monitoring (CGM) systems has facilitated the characterization and quantification of glycemic fluctuations. Over the years, several metrics for assessing glycemic variability have been developed. Children and adolescents with T1D often experience wide and frequent glycemic excursions due to behavioral and hormonal factors. Several studies suggest a potential link between glycemic variability and an increased risk of diabetes-related complications.
Glycemic variability has become an integral aspect of the routine clinical management of youths with T1D, serving as a valuable therapeutic target. However, achieving recommended glycemic targets in this population remains challenging. Further long-term data are needed to definitively establish the role of glycemic variability in the development of complications.
近年来，科学界对血糖变异性的兴趣日益浓厚，尤其是其作为糖尿病相关长期并发症独立危险因素的潜力。本叙述性综述旨在全面概述1型糖尿病（T1D）儿童和青少年的短期血糖变异性。
我们在PubMed MEDLINE数据库中使用以下搜索词组合对已发表的文献进行了检索：“血糖变异性”“儿科”“1型糖尿病”和“儿童”。
连续血糖监测（CGM）系统的广泛应用促进了血糖波动的特征描述和量化。多年来，已开发出多种评估血糖变异性的指标。由于行为和激素因素，T1D儿童和青少年经常经历广泛且频繁的血糖波动。多项研究表明血糖变异性与糖尿病相关并发症风险增加之间可能存在联系。
血糖变异性已成为T1D青少年常规临床管理的一个组成部分，是一个有价值的治疗靶点。然而，在这一人群中实现推荐的血糖目标仍然具有挑战性。需要进一步的长期数据来明确确定血糖变异性在并发症发生发展中的作用。
