维持无麸质饮食：改善1型糖尿病合并乳糜泻青少年血糖指标的关键。
Maintaining the gluten-free diet: The key to improve glycemic metrics in youths with type 1 diabetes and celiac disease.
作者信息
Mozzillo Enza, Marigliano Marco, Cuccurullo Irene, Berchielli Federica, Auricchio Renata, Maffeis Claudio, Maria Rosanio Francesco, Iafusco Dario, Pedrolli Carlo, Pertile Riccardo, Delvecchio Maurizio, Passanisi Stefano, Salzano Giuseppina, Di Candia Francesca, Franceschi Roberto
机构信息
Department of Translational Medical Science, University of Naples Federico II, Naples, Italy; European Laboratory for the Investigation of Food-Induced Diseases, University of Naples Federico II, Naples, Italy.
Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
出版信息
Diabetes Res Clin Pract. 2024 Jan;207:111074. doi: 10.1016/j.diabres.2023.111074. Epub 2023 Dec 22.
AIMS
Gluten-free diets (GFD) were considered as high glycemic index and/or high content of saturated fats; this could affect keeping good metabolic control in individuals with both type 1 diabetes (T1D) and celiac disease (CD). Our objective was to analyze time in range and other continuous glucose monitoring (CGM) metrics with real-time CGM systems, in youths with T1D and CD, compared to those with T1D only.
METHODS
An observational case-control study, comparing youths aged 8-18 years with T1D and CD, with people with T1D only was performed. The degree of maintaining GFD was assessed through anti-tissue transglutaminase antibodies and dietary interview, and maintaining Mediterranean diet through the KIDMED questionnaire.
RESULTS
86 youths with T1D and CD, 167 controls with T1D only, were included in the study and the two groups reported similar real-time CGM metrics. Among the first group, 29 % were not completely maintaining GFD and compared to people with T1D only they showed higher hyperglycemia rates (% time above range: 38.72 ± 20.94 vs 34.34 ± 20.94; P = 0.039).
CONCLUSIONS
Individuals with T1D and CD who maintain GFD presented similar glucose metrics compared to youths with T1D only. Individuals not strictly maintaining GFD presented higher hyperglycemia rates.
目的
无麸质饮食（GFD）被认为具有高血糖指数和/或高饱和脂肪含量；这可能会影响1型糖尿病（T1D）和乳糜泻（CD）患者维持良好的代谢控制。我们的目标是通过实时连续血糖监测（CGM）系统，分析T1D合并CD的青少年与仅患有T1D的青少年相比，血糖达标时间及其他CGM指标。
方法
开展一项观察性病例对照研究，比较8至18岁的T1D合并CD的青少年与仅患有T1D的人群。通过抗组织转谷氨酰胺酶抗体和饮食访谈评估维持GFD的程度，并通过KIDMED问卷评估维持地中海饮食的情况。
结果
86名T1D合并CD的青少年和167名仅患有T1D的对照者纳入研究，两组报告的实时CGM指标相似。在第一组中，29%的人未完全维持GFD，与仅患有T1D的人相比，他们的高血糖发生率更高（血糖高于目标范围的时间百分比：38.72±20.94 vs 34.34±20.94；P=0.039）。
结论
与仅患有T1D的青少年相比，维持GFD的T1D合并CD患者的血糖指标相似。未严格维持GFD的患者高血糖发生率更高。
Zotero 插件