Dos Santos Anne Caroline Rodrigues, Laurindo Renata Pereira, Pestana Fernanda Marques, Heringer Luiza Dos Santos, Canedo Nathalie Henrique Silva, Martinez Ana Maria Blanco, Marques Suelen Adriani
Graduate Program in Pathological Anatomy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Neurobiology Department, Institute of Biology, Federal Fluminense University, Rio de Janeiro, Brazil.
Neurotrauma Rep. 2024 Jul 31;5(1):721-737. doi: 10.1089/neur.2024.0023. eCollection 2024.
Traumatic spinal cord injury (SCI) causes debilitating motor and sensory deficits that impair functional performance, and physical rehabilitation is currently the only established therapeutic reality in the clinical setting. In this study, we aimed to assess the effect of exercise of different volume and timing of intervention on functional recovery and neuromuscular regeneration in a mouse model of compressive SCI. Mice were assigned to one of four groups: laminectomy only (SHAM); injured, without treadmill training (SCI); injured, treadmill trained for 10 min until day 56 postinjury (TMT1); and injured, treadmill trained for two 10-min cycles with a 10-min pause between them until day 28 postinjury followed by the TMT1 protocol until day 56 postinjury (TMT3). On day 7 postinjury, animals started an eight-week treadmill-training exercise protocol and were trained three times a week. TMT3 mice had the best results in terms of neuroregeneration, functional recovery, and muscle plasticity as measured by functional and morphometric parameters. In conclusion, the volume of exercise can modulate the quality of the regenerative response to injury, when started in the acute phase and adjusted according to the inflammatory window.
创伤性脊髓损伤（SCI）会导致使人衰弱的运动和感觉功能障碍，从而损害功能表现，而物理康复是目前临床环境中唯一已确立的治疗方法。在本研究中，我们旨在评估不同运动量和干预时机的运动对压迫性SCI小鼠模型功能恢复和神经肌肉再生的影响。将小鼠分为四组之一：仅行椎板切除术（假手术组）；损伤但未进行跑步机训练（SCI组）；损伤后进行跑步机训练，每天训练10分钟，直至损伤后56天（TMT1组）；损伤后进行跑步机训练，每天进行两个10分钟的训练周期，中间间隔10分钟，直至损伤后28天，然后按照TMT1方案训练至损伤后56天（TMT3组）。在损伤后第7天，动物开始为期八周的跑步机训练运动方案，每周训练三次。通过功能和形态学参数测量，TMT3组小鼠在神经再生、功能恢复和肌肉可塑性方面取得了最佳结果。总之，当在急性期开始并根据炎症窗口期进行调整时，运动量可以调节对损伤的再生反应质量。
