Heyns Ingrid Marie, Faunce Alina Farah, Mumba Mercy Ngosa, Kumar M N V Ravi, Arora Meenakshi
The Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, Alabama 35401, United States.
Department of Translational Science and Medicine, College of Community Health Sciences, The University of Alabama, Tuscaloosa, Alabama 35401, United States.
ACS Pharmacol Transl Sci. 2024 May 27;7(8):2237-2250. doi: 10.1021/acsptsci.4c00158. eCollection 2024 Aug 9.
Opioids are commonly prescribed to address intense, ongoing pain associated with cancer, as well as long-lasting noncancer-related pain when alternative methods have proven ineffective. Individuals who exhibit both chronic pain and misuse of opioids face a significant danger of experiencing adverse health outcomes and the potential loss of life related to opioid use. Thus, there is a current movement to prescribe naloxone to those considered high-risk for opioid overdose. Naloxone has been explored as an antidote to reverse acute respiratory depression. Conversely, naloxone can give rise to other problems, including hypertension and cardiac arrhythmias. Thus, the importance of nanotechnology-enabled drug delivery strategies and their role in mitigating naloxone side-effects are significant. In this review, we explore the latest advancements in nanotechnology-enabled naloxone and alternative methods for addressing the opioid crisis through the utilization of non-opioid natural alternatives for chronic pain management.
阿片类药物通常用于治疗与癌症相关的剧烈、持续性疼痛，以及在其他替代方法被证明无效时治疗长期的非癌症相关疼痛。同时患有慢性疼痛和滥用阿片类药物的个体面临着出现不良健康后果以及因使用阿片类药物而有潜在生命损失的重大风险。因此，目前有一项举措是为那些被认为有阿片类药物过量高风险的人开纳洛酮。纳洛酮已被研究作为一种逆转急性呼吸抑制的解毒剂。相反，纳洛酮会引发其他问题，包括高血压和心律失常。因此，基于纳米技术的药物递送策略的重要性及其在减轻纳洛酮副作用方面的作用意义重大。在这篇综述中，我们探讨了基于纳米技术的纳洛酮的最新进展，以及通过利用非阿片类天然替代品进行慢性疼痛管理来解决阿片类药物危机的替代方法。
