Li Dong-Yun, Sun Wei, Zhou Xiao-Tao, Wen Yu, Zou Yang
University of Electronic Science and Technology of China, Chengdu, China.
Department of Nephrology, Sichuan Provincial Ziyang People's Hospital, Ziyang, China.
Front Med (Lausanne). 2024 Jul 31;11:1391057. doi: 10.3389/fmed.2024.1391057. eCollection 2024.
This study aims to explore the relationship between cardiovascular calcification (CVC) and serum levels of high-density lipoprotein cholesterol (HDL-C) and its subfractions in hemodialysis (HD) patients.
HD patients and healthy participants were recruited based on specific inclusion and exclusion criteria. Various blood indicators were measured, and demographic information was recorded. HDL-C particle levels were quantified using lipophilic fluorescent dye staining and capillary electrophoresis (microfluidic platform). Coronary artery calcium scores and valve calcification were used to classify HD patients into calcification and non-calcification groups.
Compared to healthy participants, HD patients showed a significant increase in HDL-C, high-density lipoprotein 2 cholesterol (HDL2-C), and high-density lipoprotein 3 cholesterol (HDL3-C) levels ( < 0.001). Further division of HD patients into calcification and non-calcification groups revealed higher serum HDL3-C concentrations ( = 0.002) and a higher HDL3-C/HDL-C ratio ( = 0.04) in the calcification group. Additionally, elevated HDL3-C levels were found to be an independent risk factor for CVC in HD patients ( = 0.040). The ROC curve analysis showed an AUC value of 0.706 for HDL3-C ( = 0.002).
Our study indicates that elevated serum HDL3-C levels in HD patients are an independent risk factor for CVC and can serve as a potential predictor for CVC events. However, more studies need to verify its potential as a predictive indicator..
本研究旨在探讨血液透析（HD）患者心血管钙化（CVC）与血清高密度脂蛋白胆固醇（HDL-C）及其亚组分水平之间的关系。
根据特定的纳入和排除标准招募HD患者和健康参与者。测量各种血液指标，并记录人口统计学信息。使用亲脂性荧光染料染色和毛细管电泳（微流控平台）对HDL-C颗粒水平进行定量。采用冠状动脉钙化评分和瓣膜钙化将HD患者分为钙化组和非钙化组。
与健康参与者相比，HD患者的HDL-C、高密度脂蛋白2胆固醇（HDL2-C）和高密度脂蛋白3胆固醇（HDL3-C）水平显著升高（<0.001）。将HD患者进一步分为钙化组和非钙化组后发现，钙化组的血清HDL3-C浓度更高（=0.002），HDL3-C/HDL-C比值更高（=0.04）。此外，HDL3-C水平升高被发现是HD患者CVC的独立危险因素（=0.040）。ROC曲线分析显示，HDL3-C的AUC值为0.706（=0.002）。
我们的研究表明，HD患者血清HDL3-C水平升高是CVC的独立危险因素，可作为CVC事件的潜在预测指标。然而，需要更多研究来验证其作为预测指标的潜力。
