Cardiac Surgery Division, Surgical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, Italy.
Anesthesiology and Intensive Care Division, Surgical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, Italy.
Transpl Int. 2024 Jul 31;37:13178. doi: 10.3389/ti.2024.13178. eCollection 2024.
The key goal in lung donation remains the improvement of graft preservation with the ultimate objective of increasing the number and quality of lung transplants (LTx). Therefore, in recent years the field of graft preservation focused on improving outcomes related to solid organ regeneration and restoration. In this contest Ex-Vivo Lung Perfusion (EVLP) plays a crucial role with the purpose to increase the donor pool availability transforming marginal and/or declined donor lungs suitable for transplantation. Aim of this proof of concept is to test the safety, suitability and feasibility of a new tilting dome for EVLP designed considering the dorsal lung areas as the "Achilles' heel" of the EVLP due to a more fluid accumulation than in the supine standard position.
肺移植的关键目标仍然是改善供肺保存，最终目标是增加肺移植（LTx）的数量和质量。因此，近年来，供肺保存领域的重点是改善与实体器官再生和修复相关的结果。在这方面，离体肺灌注（EVLP）起着至关重要的作用，其目的是增加供肺库的可用性，将边缘供肺和/或功能下降的供肺转化为适合移植的供肺。本概念验证的目的是测试一种新的倾斜穹顶在 EVLP 中的安全性、适用性和可行性，该穹顶的设计考虑了背侧肺区域，因为背侧肺区域比标准仰卧位更容易出现更多的液体积聚，是 EVLP 的“阿喀琉斯之踵”。
