Su Hongyan, Wang Xiancheng, Wang Lu, Yuan Na
Cardiology Department, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, 130000, China.
Rheumatology Department, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, 30000, China.
Cell Biochem Biophys. 2025 Mar;83(1):73-86. doi: 10.1007/s12013-024-01481-9. Epub 2024 Aug 15.
Atherosclerosis (AS), a potentially fatal cardiovascular disease (CVD), is a chronic inflammatory condition. The disease's onset and progression are influenced by inflammatory and immunological mechanisms. The innate immune pathways are essential in the progression of AS, as they are responsible for detecting first danger signals and causing long-term changes in immune cells. The innate immune system possesses distinct receptors known as pattern recognition receptors (PRRs) which can identify both pathogen-associated molecular patterns and danger-associated molecular signals. Activation of PRRs initiates the inflammatory response in various physiological systems, such as the cardiovascular system. This review specifically examines the contribution of the innate immune response and PRRs to the formation and advancement of AS. Studying the role of these particular receptors in AS would enhance our understanding of the development of AS and offer novel approaches for directly improving the inflammatory response associated with it.
动脉粥样硬化（AS）是一种潜在致命的心血管疾病（CVD），是一种慢性炎症性疾病。该疾病的发生和发展受炎症和免疫机制的影响。固有免疫途径在AS的进展中至关重要，因为它们负责检测最初的危险信号并引起免疫细胞的长期变化。固有免疫系统拥有称为模式识别受体（PRR）的独特受体，这些受体可以识别病原体相关分子模式和危险相关分子信号。PRR的激活会引发各种生理系统（如心血管系统）中的炎症反应。本综述专门研究固有免疫反应和PRR对AS形成和进展的贡献。研究这些特定受体在AS中的作用将增强我们对AS发展的理解，并为直接改善与之相关的炎症反应提供新方法。
