Department of Surgery, Tri-Service General Hospital Keelung Branch, Keelung, Taiwan; Department of Orthopedic Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
School of Medicine, National Defense Medical Center, Taipei, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Int Immunopharmacol. 2024 Nov 15;141:112863. doi: 10.1016/j.intimp.2024.112863. Epub 2024 Aug 14.
Rheumatoid arthritis (RA) is an autoimmune disease that causes persistent inflammation involving the joints, cartilage, and synovium. In individuals with RA, alterations in the composition of intestinal bacteria suggest the vital role of gut microbiota in immune dysfunction. Multiple therapies commonly used to treat RA can also alter the diversity of gut microbiota, further suggesting the modulation of gut microbiota as a prevention or treatment for RA. Therefore, a better understanding of the changes in the gut microbiota that accompany RA should facilitate the development of novel therapeutic approaches. In this study, B. coagulans BACO-17 not only significantly reduced paw swelling, arthritis scores, and hind paw and forepaw thicknesses but also protected articular cartilage and the synovium against RA degeneration, with a corresponding downregulation of TNF-α expression. The inhibition or even reversing of RA progression highlights B. coagulans BACO-17 as a novel therapeutic for RA worth investigating.
类风湿性关节炎（RA）是一种自身免疫性疾病，可导致关节、软骨和滑膜的持续炎症。在 RA 患者中，肠道细菌组成的改变表明肠道微生物群在免疫功能障碍中起着至关重要的作用。常用于治疗 RA 的多种疗法也可以改变肠道微生物群的多样性，这进一步表明调节肠道微生物群作为 RA 的预防或治疗方法。因此，更好地了解伴随 RA 的肠道微生物群的变化将有助于开发新的治疗方法。在这项研究中，凝结芽孢杆菌 BACO-17 不仅显著减少了爪肿胀、关节炎评分以及后爪和前爪的厚度，而且还保护了关节软骨和滑膜免受 RA 退化的影响，同时 TNF-α 的表达也相应下调。RA 进展的抑制甚至逆转突出了凝结芽孢杆菌 BACO-17 作为一种有前途的 RA 治疗方法，值得进一步研究。
