寻找与肥胖相关的肠道微生物组 enterotype。

Fishing for obesity-related gut microbiome enterotype.

机构信息

Fudan Microbiome Center, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, and Center for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.

出版信息

Cell Host Microbe. 2024 Aug 14;32(8):1209-1211. doi: 10.1016/j.chom.2024.07.002.

DOI:10.1016/j.chom.2024.07.002

PMID:39146789

Abstract

Despite debate, the concept of enterotype-like clusters remains valuable for exploring the human gut microbiome and associated environmental factors. In this issue of Cell Host & Microbe, Wu et al. robustly identified an obesity-related enterotype-like cluster, Megamonas, and demonstrated its clinical relevance through cohort studies, mice, and cell experiments.

摘要

尽管存在争议，但类似肠型的聚类概念对于探索人类肠道微生物组和相关环境因素仍然具有重要价值。在本期《Cell Host & Microbe》中，Wu 等人通过队列研究、小鼠和细胞实验，强有力地鉴定出了一个与肥胖相关的类似肠型的聚类，即 Megamonas，并证明了其临床相关性。