Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Military Medical University (Second Military Medical University), Shanghai, 200433, China.
Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Military Medical University (Second Military Medical University), Shanghai, 200433, China.
Free Radic Biol Med. 2024 Nov 1;224:50-61. doi: 10.1016/j.freeradbiomed.2024.08.009. Epub 2024 Aug 13.
Hydrogen-rich water (HRW) is a beverage containing a high concentration of hydrogen that has been researched for its antioxidant, anti-apoptotic, and anti-inflammatory properties in asthma. This study investigates the potential therapeutic impact of HRW on the gut-lung axis. Using 16S rRNA and serum metabolomics, we examined changes in gut microbiota and serum metabolites in asthmatic mice after HRW intervention, followed by validation experiments. The findings revealed that HRW influenced gut microbiota by increasing Ligilactobacillus and Bifidobacterium abundance and enhancing the presence of indole-3-acetic acid (IAA), a microbially derived serum metabolite. Both in vivo and in vitro experiments showed that HRW's protective effects against airway inflammation in asthmatic mice may be linked to the gut microbiota, with IAA potentially playing a role in reducing asthmatic airway inflammation through the aryl hydrocarbon receptors (AhR) signaling pathway. In summary, HRW can modify gut microbiota, increase Bifidobacterium abundance, elevate microbial-derived IAA levels, and activate AhR, which could potentially alleviate inflammation in asthma.
富氢水（HRW）是一种含有高浓度氢气的饮料，其在哮喘中的抗氧化、抗细胞凋亡和抗炎特性已被广泛研究。本研究探讨了 HRW 对肠-肺轴的潜在治疗作用。通过 16S rRNA 和血清代谢组学，我们研究了 HRW 干预后哮喘小鼠的肠道微生物群和血清代谢物的变化，并进行了验证实验。结果表明，HRW 通过增加乳杆菌属和双歧杆菌属的丰度以及增强微生物衍生的血清代谢物吲哚-3-乙酸（IAA）的存在来影响肠道微生物群。体内和体外实验均表明，HRW 对哮喘小鼠气道炎症的保护作用可能与肠道微生物群有关，IAA 可能通过芳香烃受体（AhR）信号通路降低哮喘气道炎症。总之，HRW 可以调节肠道微生物群，增加双歧杆菌属的丰度，提高微生物衍生的 IAA 水平，并激活 AhR，从而可能缓解哮喘中的炎症。
