School of Public Health and the Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, PR China; The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Hangzhou, Zhejiang 310058, PR China.
Department of Orthopaedics, Affiliated Zhejiang Hospital of School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, PR China.
J Affect Disord. 2024 Nov 15;365:49-55. doi: 10.1016/j.jad.2024.08.075. Epub 2024 Aug 13.
The association between body shape and depressive symptoms has been reported in adults. The present study aimed to investigate the association between body shape-specific abdominal obesity and depressive symptoms among multi-regional Asian adults.
The 2011-2012 China Health and Retirement Longitudinal Study and 2022-2023 Hangzhou study were used as the discovery and validation datasets, respectively. Body shape was assessed by body mass index categories. Abdominal obesity was defined as a body shape index (ABSI) ≥ 75th centile. Depression was measured using 10-item Centre for Epidemiological Studies Depression Scale and Geriatric Depression Scale short 15-item version, respectively. General linear and multinomial logistic models were used to explore the association of ABSI, abdominal obesity with depressive scores and presence, respectively.
A total of 12,229 and 1210 participants were included in the discovery and validation datasets, respectively. A non-linear reverse L-shaped association was found between ABSI and depressive scores. Participants with abdominal obesity had higher depressive scores (β = 0.05, 95%CI = 0.01-0.09; and β = 0.13, 95%CI = 0.01-0.24; respectively). Stratified analyses showed that abdominal obesity was associated with higher depressive scores (β = 0.09, 95%CI = 0.00-0.17; and β = 0.25, 95%CI = 0.05-0.46; respectively) and presence (OR = 1.46, 95%CI = 1.02-2.10; and OR = 3.95, 95%CI = 1.58-9.84; respectively) in overweight adults. Furthermore, abdominal obesity was associated with depressive symptoms among overweight females, but not among males.
Causal links weren't addressed because of the observational study design.
Abdominal obesity exhibited a positive association with depressive symptoms among Asian overweight adults, particularly in females. Prevention and early diagnosis of depressive symptoms should focus on overweight females.
身体形态与抑郁症状之间的关系在成年人中已有报道。本研究旨在探讨特定于身体形态的腹部肥胖与多地区亚洲成年人抑郁症状之间的关系。
使用 2011-2012 年中国健康与退休纵向研究和 2022-2023 年杭州研究作为发现和验证数据集。身体形态通过体重指数类别进行评估。腹部肥胖定义为身体形态指数(ABSI)≥第 75 百分位数。抑郁使用 10 项中心流行病学研究抑郁量表和老年抑郁量表短 15 项版本分别进行测量。使用一般线性和多项逻辑回归模型分别探讨 ABSI、腹部肥胖与抑郁评分和存在的关联。
共有 12229 名和 1210 名参与者分别纳入发现和验证数据集。发现 ABSI 与抑郁评分之间存在非线性反向 L 形关联。腹部肥胖的参与者抑郁评分较高(β=0.05,95%CI=0.01-0.09;β=0.13,95%CI=0.01-0.24)。分层分析表明,腹部肥胖与较高的抑郁评分(β=0.09,95%CI=0.00-0.17;β=0.25,95%CI=0.05-0.46)和存在(OR=1.46,95%CI=1.02-2.10;OR=3.95,95%CI=1.58-9.84)相关超重成年人。此外,腹部肥胖与超重女性的抑郁症状相关,但与男性无关。
由于观察性研究设计,无法确定因果关系。
腹部肥胖与亚洲超重成年人的抑郁症状呈正相关,尤其是女性。预防和早期诊断抑郁症状应重点关注超重女性。