KKT Technology Pte. Ltd., 71 Ayer Rajah Crescent, Singapore 139951.
KKT Technology Pte. Ltd., 71 Ayer Rajah Crescent, Singapore 139951.
J Affect Disord. 2024 Nov 15;365:73-79. doi: 10.1016/j.jad.2024.08.055. Epub 2024 Aug 13.
While PTSD is commonly associated with multiple comorbidities, studies have yet to quantify the impact of these comorbidities on key clinical outcomes and HCRU. This study explored risks of emergency room (ER) visits, inpatient admissions (IA), suicidal ideation (SI), and treatment follow-up duration (FU), amongst PTSD patients with comorbid MDD and/or SUD.
Using real-world data (RWD) generated by electronic health records accessed from the NeuroBlu database, a cohort of adolescent patients (12-17 yrs) was examined over a one-year study period following PTSD diagnosis.
5794 patients were included in the cohort. Compared to patients with only PTSD (n = 3061), those with comorbid MDD (n = 1820) had greater odds of ER (4.5 times), IA (1.6 times), and FU (4.3 times). Those with comorbid SUD (n = 653) had greater odds of IA (4.5 times), shorter FU (34 days), and lower odds of ER (0.5 times). Both comorbidities (n = 260) had greater odds of ER (3.8 times), IA (2.6 times), SI (3.6 times), and shorter FU (12 days).
These RWD had a high proportion of missingness. Health records of patients who changed service providers could not be accounted for in this study.
Both MDD and SUD substantially elevated the risk of HCRU and suicidal ideation for PTSD patients.
虽然 PTSD 通常与多种合并症相关，但研究尚未量化这些合并症对关键临床结局和 HCRU 的影响。本研究探讨了 PTSD 合并 MDD 和/或 SUD 的患者发生急诊就诊（ER）、住院治疗（IA）、自杀意念（SI）和治疗随访时间（FU）的风险。
本研究使用从 NeuroBlu 数据库获取的电子健康记录生成的真实世界数据（RWD），对 PTSD 诊断后一年的青少年患者队列进行了研究。
该队列共纳入 5794 名患者。与仅患有 PTSD 的患者（n=3061）相比，患有 MDD 合并症的患者（n=1820）发生 ER 的可能性更高（4.5 倍）、IA（1.6 倍）和 FU（4.3 倍）。患有 SUD 合并症的患者（n=653）发生 IA 的可能性更高（4.5 倍）、FU 更短（34 天）和 ER 可能性较低（0.5 倍）。同时患有两种合并症的患者（n=260）发生 ER 的可能性更高（3.8 倍）、IA（2.6 倍）、SI（3.6 倍）和 FU 更短（12 天）。
这些 RWD 存在较高比例的缺失值。本研究未考虑到更换服务提供者的患者的健康记录。
MDD 和 SUD 都会显著增加 PTSD 患者的 HCRU 和自杀意念风险。
