Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 999077, China.
J Mol Cell Cardiol. 2024 Oct;195:97-102. doi: 10.1016/j.yjmcc.2024.08.004. Epub 2024 Aug 13.
As the innermost monolayer of the vasculature, endothelial cells (ECs) serve as the interface for multiplex signal transduction. Directly exposed to blood-borne factors, both endogenous and exogenous, ECs actively mediate vascular homeostasis and represent a therapeutic target against cardiometabolic diseases. ECs act as the first-line gateway between gut-derived substances and vasculature. Additionally, ECs convert blood flow-exerted hemodynamic forces into downstream biochemical signaling to modulate vascular pathophysiology. Besides, ECs can sense other forms of stimuli, like cell extrusion, thermal stimulation, photostimulation, radiation, magnetic field, noise, and gravity. Future efforts are still needed to deepen our understanding on endothelial biology.
作为脉管系统的最内层单层，内皮细胞 (ECs) 充当了多种信号转导的界面。由于直接暴露于血液来源的内源性和外源性因子，ECs 积极介导血管稳态，并成为针对心脏代谢疾病的治疗靶点。ECs 充当了肠道来源物质与脉管系统之间的第一道门户。此外，ECs 将血流施加的血流动力学力转化为下游生化信号，以调节血管病理生理学。除此之外，ECs 还可以感知其他形式的刺激，如细胞挤出、热刺激、光刺激、辐射、磁场、噪声和重力。未来仍需要进一步努力来加深我们对内皮生物学的理解。
