Ozawa A, Sawamura S, Yanagawa Y, Nagao T, Sasaki S
Tokai J Exp Clin Med. 1985 Jun;10(2-3):181-92.
The result documenting the disappearance of obligate anaerobic bacteria as the predominant intestinal organisms with the onset of septicemia from S. marcescens calls for exploration into the clinical significance of anaerobic bacteria in the intestine in relationships between gut flora and host. The finding that no significant difference could be seen between the rates of septicemia under protective isolation and in uncontrolled environments is indicative of the fact that the disease most likely originated as an infection of endogenous nature. In the five cases of leukemia in children with bone marrow transplantation cited in this presentation, not one case of bacterial or fungal infection was recorded. The establishment of endogenous infections surrounding the results presented herein is discussed in terms of the biological phenomena of the interaction between intestinal flora and host, and between the intestinal bacterial flora.
随着粘质沙雷氏菌败血症的发生，专性厌氧菌作为主要肠道微生物消失的结果，要求探讨肠道厌氧菌在肠道菌群与宿主关系中的临床意义。在保护性隔离和非受控环境下败血症发生率之间未观察到显著差异，这一发现表明该疾病很可能起源于内源性感染。在本报告引用的5例儿童骨髓移植白血病病例中，未记录到一例细菌或真菌感染。本文围绕这些结果对内源性感染的形成，从肠道菌群与宿主之间以及肠道细菌菌群之间相互作用的生物学现象方面进行了讨论。
