囊性纤维化跨膜传导调节因子与结直肠癌易感性：迫切需要进一步研究。
CFTR and colorectal cancer susceptibility: an urgent need for further studies.
作者信息
Spelier S, Derksen S, Hofland R, Beekman J M, Yetkin-Arik B
机构信息
Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, The Netherlands.
Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, The Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, The Netherlands.
出版信息
Trends Cancer. 2024 Oct;10(10):876-879. doi: 10.1016/j.trecan.2024.07.006. Epub 2024 Aug 14.
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in cystic fibrosis, a multiorgan disease characterized by aberrant epithelial cell fluid secretion. Recent studies describe a connection between CFTR malfunctioning and a heightened susceptibility to colorectal cancer (CRC). Here, we outline these links and suggest directions for further studies.
囊性纤维化跨膜传导调节因子（CFTR）基因突变会导致囊性纤维化，这是一种多器官疾病，其特征是上皮细胞液分泌异常。最近的研究描述了CFTR功能障碍与结直肠癌（CRC）易感性增加之间的联系。在此，我们概述了这些联系，并提出了进一步研究的方向。
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