Zhu Liu-Rong, He Xue-Hua, Yuan Yong-Hua, Yuan Hao, Xia Xiao-Hui
Department of Pediatrics, First Affiliated Hospital of Hunan Normal University, Changsha 410005, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2024 Aug 15;26(8):829-834. doi: 10.7499/j.issn.1008-8830.2403056.
To investigate the changes in the serum levels of oxidized phospholipids (OxPLs) and endothelial nitric oxide synthase (eNOS) and their association with coronary artery disease (CAL) in children in the acute stage of Kawasaki disease (KD), as well as the clinical significance of OxPLs and eNOS.
A prospective study was conducted on 95 children in the acute stage of KD (KD group). According to the presence of absence of CAL, the KD group was further divided into a CAL subgroup and a non-CAL (NCAL) subgroup. Thirty children with fever due to lower respiratory tract infection were enrolled as the fever group. Thirty healthy children who underwent physical examination were enrolled as the healthy control group. The above groups were compared in terms of general information and serum levels of OxPLs, eNOS and other laboratory indexes, and the correlation between OxPLs level and eNOS level was analyzed.
The KD group had a significantly higher level of OxPLs and a significantly lower level of eNOS compared with the fever group and the healthy control group (<0.05). After treatment, the children with KD had a significantly decreased OxPLs level and a significantly increased eNOS level (<0.05). Compared with the NCAL subgroup, the CAL subgroup had a significantly higher level of OxPLs and a significantly lower level of eNOS (<0.05). Among the children of KD, the level of OxPLs was negatively correlated with that of eNOS (=-0.353, <0.05).
Serum OxPLs and eNOS in the acute stage of KD may be involved in the development of CAL in children with KD, and therefore, they may be used as the biomarkers to predict CAL in these children.
探讨川崎病（KD）急性期患儿血清氧化磷脂（OxPLs）和内皮型一氧化氮合酶（eNOS）水平变化及其与冠状动脉病变（CAL）的关系，以及OxPLs和eNOS的临床意义。
对95例KD急性期患儿（KD组）进行前瞻性研究。根据是否存在CAL，将KD组进一步分为CAL亚组和非CAL（NCAL）亚组。纳入30例因下呼吸道感染发热的患儿作为发热组。纳入30例接受体检的健康儿童作为健康对照组。比较上述各组的一般资料以及OxPLs、eNOS血清水平和其他实验室指标，并分析OxPLs水平与eNOS水平的相关性。
与发热组和健康对照组相比，KD组OxPLs水平显著升高，eNOS水平显著降低（<0.05）。治疗后，KD患儿OxPLs水平显著降低，eNOS水平显著升高（<0.05）。与NCAL亚组相比，CAL亚组OxPLs水平显著升高，eNOS水平显著降低（<0.05）。在KD患儿中，OxPLs水平与eNOS水平呈负相关（r=-0.353，<0.05）。
KD急性期患儿血清OxPLs和eNOS可能参与KD患儿CAL的发生发展，因此，它们可作为预测这些患儿CAL的生物标志物。
