Zhang Jing, Qiu Jieyuzhen, Wu Lipan, Shen Lin, Gu Qin, Tan Wen
Department of Endocrinology, Huadong Hospital Affiliated to Fudan University, Shanghai, P. R. China.
Department of Hematology, Huadong Hospital Affiliated to Fudan University, Shanghai, P. R. China.
Clin Med Insights Case Rep. 2024 Aug 13;17:11795476241271540. doi: 10.1177/11795476241271540. eCollection 2024.
Hypoglycemia is a rare complication of diffuse large B-cell lymphoma. We are presenting a case of 67-year-old woman presented to her primary care physician with fatigue and hyperhidrosis. Laboratory evaluation revealed a glucose level of 1.9 mmol/L. Computed tomographic scan of the abdomen and subsequent positron emission tomographic scan revealed extensive lymphadenopathy. The patient was then diagnosed with -diffuse large B-cell lymphoma and developed recurrent hypoglycemia despite continuous infusion of glucose. Following immunochemotherapy, hypoglycemia was resolved. Several explanations have been postulated but the exact pathophysiology is not well understood. Further investigation is warranted to more clearly define the pathophysiology of persistent hypoglycemia in patients with diffuse large B-cell lymphoma.
低血糖是弥漫性大B细胞淋巴瘤的一种罕见并发症。我们报告一例67岁女性，因疲劳和多汗就诊于她的初级保健医生。实验室检查显示血糖水平为1.9 mmol/L。腹部计算机断层扫描及随后的正电子发射断层扫描显示广泛淋巴结病。该患者随后被诊断为弥漫性大B细胞淋巴瘤，尽管持续输注葡萄糖仍出现反复低血糖。免疫化疗后，低血糖得到缓解。已经提出了几种解释，但确切的病理生理学尚不清楚。有必要进行进一步研究以更清楚地界定弥漫性大B细胞淋巴瘤患者持续性低血糖的病理生理学。
