Meral Gulsen, Aslan Elif S, Burkay Neval, Alper Acar Esma Gökcen, Karagöz Mustafa Fevzi, Özkaya Merve, Sahin Esra, Alp Muhammed Yunus
Molecular Biology and Genetics, Pediatrics, Epigenetic Coaching, Norwich, GBR.
Molecular Biology and Genetics, Pediatrics, Biruni University, Istanbul, TUR.
Cureus. 2024 Aug 15;16(8):e66959. doi: 10.7759/cureus.66959. eCollection 2024 Aug.
Nutrigenetics explores how genetic variations influence an individual's responses to nutrients, enabling personalized nutrition. As dietary supplements gain popularity, understanding genetic factors in their metabolism and effectiveness is crucial for optimal health outcomes. This study examines the role of genetic differences in the metabolism and effects of nutraceuticals, underscoring the significance of personalized nutrition within precision health. It aims to reveal how individual genetic profiles influence responses to dietary supplements, highlighting the value of nutrigenetics in optimizing health interventions. The study explores how genetic variations affect the absorption and effects of nutraceuticals, focusing on personalized supplement choices based on nutrigenetics.
Sixteen patients from an Epigenetic Coaching clinic who were using supplements such as quercetin, curcumin, green tea, and sulforaphane and reporting side effects were studied. Their clinical outcomes were analyzed in relation to their supplement choices and genetic backgrounds. The study involved five women and 11 men, including eight with autism and others with conditions like Hashimoto's thyroiditis (HT) disease and joint pain.
In the study, it was observed that removing sulforaphane and sulfur-rich supplements from the diet of five patients reduced agitation. Removing sulforaphane and sulfur-rich supplements from the diet of four patients reduced clinical symptoms. Green tea caused discomfort in two patients. Responses to quercetin showed clinical differences in two patients. Anxiety and hyperactivity increased in three patients who took curcumin. Conclusion This study highlights the importance of considering individual genetic profiles when recommending dietary supplements. The findings suggest that personalized nutrition, guided by nutrigenetic insights, can enhance the efficacy and safety of nutraceutical interventions. Tailoring supplement choices based on genetic information can lead to better health outcomes and reduced adverse effects, emphasizing the need for integrating genetic testing into nutritional planning and healthcare practices.
营养遗传学探索基因变异如何影响个体对营养素的反应，从而实现个性化营养。随着膳食补充剂越来越受欢迎，了解其代谢和功效中的遗传因素对于实现最佳健康结果至关重要。本研究考察了基因差异在营养保健品代谢和作用中的作用，强调了精准健康中个性化营养的重要性。其目的是揭示个体基因谱如何影响对膳食补充剂的反应，突出营养遗传学在优化健康干预措施方面的价值。该研究探讨了基因变异如何影响营养保健品的吸收和作用，重点关注基于营养遗传学的个性化补充剂选择。
对来自一家表观遗传学指导诊所的16名患者进行了研究，这些患者正在使用槲皮素、姜黄素、绿茶和萝卜硫素等补充剂并报告有副作用。分析了他们的临床结果与补充剂选择和基因背景的关系。该研究涉及5名女性和11名男性，其中包括8名自闭症患者以及其他患有桥本甲状腺炎（HT）疾病和关节疼痛等病症的患者。
在该研究中，观察到从5名患者的饮食中去除萝卜硫素和富含硫的补充剂可减轻烦躁情绪。从4名患者的饮食中去除萝卜硫素和富含硫的补充剂可减轻临床症状。绿茶使2名患者感到不适。两名患者对槲皮素的反应显示出临床差异。3名服用姜黄素的患者焦虑和多动症状加重。结论：本研究强调了在推荐膳食补充剂时考虑个体基因谱的重要性。研究结果表明，以营养遗传学见解为指导的个性化营养可以提高营养保健品干预的功效和安全性。根据基因信息定制补充剂选择可以带来更好的健康结果并减少不良反应，强调了将基因检测纳入营养规划和医疗实践的必要性。
