Reading Jean Miki, Solk Payton, Starikovsky Julia, Hasanaj Kristina, Wang Shirlene D, Siddique Juned, Sanford Stacy D, Salsman John, Horowitz Bruriah, Freeman Hannah, Alexander Jacqueline, Sauer Christina, Spring Bonnie, Victorson David, Phillips Siobhan M
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Glob Adv Integr Med Health. 2024 Aug 13;13:27536130241265669. doi: 10.1177/27536130241265669. eCollection 2024 Jan-Dec.
Opt2Move is a theory-guided moderate and vigorous physical activity (MVPA) promotion trial that uses multiphase optimization strategy (MOST) methodology to evaluate the individual and combined effects of four intervention components in a full factorial experiment among young adult cancer survivors (YACS; N = 304). All participants will receive the core mHealth MVPA intervention, which includes a Fitbit and standard self-monitoring Opt2Move smartphone application. YACS will be randomized to one of 16 conditions to receive between zero and four additional components each with two levels (yes v. no): E-Coach, buddy, general mindfulness, and MVPA-specific mindfulness.
The primary aim is to determine the individual and combined effects of the components on MVPA post-intervention (12-weeks) and at 24-week follow-up. The secondary aim is to examine how changes in MVPA are associated with patient-reported outcomes, light-intensity activity, sedentary time, and sleep duration and quality. Potential mediators and moderators of component effects will also be examined.
Results will support the selection of a package of intervention components optimized to maximize MVPA to be tested in a randomized controlled trial.
Opt2Move represents the first systematic effort to use MOST to design an optimized, scalable mHealth MVPA intervention for YACS and will lead to an improved understanding of how to effectively change YACS' MVPA and ultimately, improve health and disease outcomes.
Opt2Move是一项以理论为指导的中高强度身体活动（MVPA）促进试验，该试验采用多阶段优化策略（MOST）方法，在成年癌症幸存者（YACS；N = 304）的全因子实验中评估四个干预组件的个体和联合效果。所有参与者都将接受核心移动健康MVPA干预，其中包括一个Fitbit和标准的自我监测Opt2Move智能手机应用程序。YACS将被随机分配到16种情况中的一种，以接受零至四个额外的组件，每个组件有两个级别（是与否）：电子教练、伙伴、一般正念和特定于MVPA的正念。
主要目的是确定各组件在干预后（12周）和24周随访时对MVPA的个体和联合效果。次要目的是研究MVPA的变化如何与患者报告的结果、轻度强度活动、久坐时间以及睡眠时间和质量相关。还将研究组件效果的潜在中介因素和调节因素。
结果将支持选择一组经过优化以最大化MVPA的干预组件包，以便在随机对照试验中进行测试。
Opt2Move是首次使用MOST为YACS设计优化的、可扩展的移动健康MVPA干预措施的系统性努力，并将有助于更好地理解如何有效改变YACS的MVPA，最终改善健康和疾病结局。
