Wells Alexandria C, Lima-Junior Djalma Souza, Link Verena M, Smelkinson Margery, Krishnamurthy Siddharth R, Chi Liang, Segrist Elisha, Rivera Claudia A, Teijeiro Ana, Bouladoux Nicolas, Belkaid Yasmine
Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Biological Imaging, Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
bioRxiv. 2024 Aug 9:2024.08.09.606346. doi: 10.1101/2024.08.09.606346.
Maintenance of tissue integrity is a requirement of host survival. This mandate is of prime importance at barrier sites that are constitutively exposed to the environment. Here, we show that exposure of the skin to non-inflammatory xenobiotics promotes tissue repair; more specifically, mild detergent exposure promotes the reactivation of defined retroelements leading to the induction of retroelement-specific CD8 T cells. These T cell responses are Langerhans cell dependent and establish tissue residency within the skin. Upon injury, retroelement-specific CD8 T cells significantly accelerate wound repair via IL-17A. Collectively, this work demonstrates that tonic environmental exposures and associated adaptive responses to retroelements can be coopted to preemptively set the tissue for maximal resilience to injury.
维持组织完整性是宿主生存的必要条件。这一要求在持续暴露于环境的屏障部位至关重要。在此，我们表明皮肤暴露于非炎性异生物质可促进组织修复；更具体地说，轻度洗涤剂暴露可促进特定逆转录元件的重新激活，从而导致逆转录元件特异性CD8 T细胞的诱导。这些T细胞反应依赖于朗格汉斯细胞，并在皮肤内建立组织驻留。受伤后，逆转录元件特异性CD8 T细胞通过IL-17A显著加速伤口修复。总体而言，这项工作表明，持续性环境暴露以及对逆转录元件的相关适应性反应可被利用，从而预先使组织具备对损伤的最大恢复能力。
