动态X射线显微断层扫描与激光多普勒振动测量法的对比研究
Dynamic X-ray Microtomography vs. Laser-Doppler Vibrometry: A Comparative Study.
作者信息
Ivanovic Aleksandra, Cheng Jeffrey Tao, Schmeltz Margaux, Schlepütz Christian M, Bonnin Anne, Anschuetz Lukas
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Switzerland, 2Hearing Research Laboratory, ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland, Paul Scherrer Institut, Swiss Light Source, Villigen PSI, Switzerland.
Department of Otolaryngology, Head and Neck Surgery, Mass. Eye and Ear, Boston Children Hospital, Harvard Medical School, Boston, 02114, MA, USA.
出版信息
Res Sq. 2024 Aug 8:rs.3.rs-4874430. doi: 10.21203/rs.3.rs-4874430/v1.
PURPOSE
There are challenges in understanding the biomechanics of the human middle ear, and established methods for studying this system show significant limitations. In this study, we evaluate a novel dynamic imaging technique based on synchrotron X-ray microtomography designed to assess the biomechanical properties of the human middle ear by comparing it to laser-Doppler vibrometry (LDV).
METHODS
We examined three fresh-frozen temporal bones (TB) using dynamic synchrotron-based X-ray microtomography for 256 Hz and 512 Hz, stimulated at 110 dB and 120 dB SPL. In addition, we performed measurements on these TBs using 1D LDV, a well-established method.
RESULTS
The normalized displacement values (μm/Pa) at the umbo and the posterior crus of the stapes are consistent or within 5-10 dB differences between all LDV and dynamic microtomography measurements and previously reported literature references. In general, the overall behavior is similar between the two measurement techniques.
CONCLUSION
In conclusion, our results demonstrate the suitability of dynamic synchrotron-based X-ray microtomography in studying the middle ear's biomechanics. However, this study shows that better standardization regarding acoustic stimulation and measurement points is needed to better compare the two measurement techniques.
目的
理解人类中耳的生物力学存在挑战，现有的研究该系统的方法存在显著局限性。在本研究中，我们评估一种基于同步加速器X射线显微断层扫描的新型动态成像技术，旨在通过与激光多普勒振动测量法（LDV）比较来评估人类中耳的生物力学特性。
方法
我们使用基于同步加速器的动态X射线显微断层扫描对三块新鲜冷冻颞骨（TB）进行了检查，频率为256 Hz和512 Hz，声压级分别为110 dB和120 dB SPL。此外，我们还使用成熟的一维LDV方法对这些颞骨进行了测量。
结果
在所有LDV测量、动态显微断层扫描测量以及先前报道的文献参考中，镫骨脐和镫骨后脚处的归一化位移值（μm/Pa）是一致的，或者相差在5 - 10 dB以内。总体而言，两种测量技术的整体行为相似。
结论
总之，我们的结果证明了基于同步加速器的动态X射线显微断层扫描在研究中耳生物力学方面的适用性。然而，本研究表明，为了更好地比较这两种测量技术，需要在声刺激和测量点方面进行更好的标准化。
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