Ou Yiwen, Qiu Minghui, Li Mengyuan, Mi Yajun, Wu Dezheng, Tang Shibo, Dai Weiwei, Ma Jacey Hongjie
Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Department of Retinal and Vitreous Diseases, Foshan Aier Eye Hospital, Foshan, Guangdong, China.
Ophthalmol Sci. 2024 May 22;4(6):100554. doi: 10.1016/j.xops.2024.100554. eCollection 2024 Nov-Dec.
To investigate the risk factors for patients with focal choroidal excavation (FCE) and their correlation with chorioretinal diseases.
Retrospective cross-sectional study.
Patients with FCE were enrolled, while healthy subjects were recruited for the control group.
The study collected demographic information, clinical features, and multimodal images. Parameters of FCE identified using spectral-domain OCT (SD-OCT) were manually measured using built-in software and subsequently analyzed statistically.
Subfoveal choroidal thickness (SFCT), subexcavation choroidal thickness (SECT), and the greatest depth and width of each excavation were manually measured using built-in calipers in OCT software.
Twenty-one patients (13/8, male/female) with FCE were included in this study. The average age was 45.2 years, and their best-corrected visual acuity (BCVA) was 0.4 logarithm of the minimum angle of resolution (Snellen equivalent, 20/50). Focal choroidal excavation was present in 28 eyes of 21 patients, including isolated FCE (12 eyes) and complicated FCE (16 eyes) with choroidal neovascularization (sCNV), central serous chorioretinopathy, and other conditions. Patients with complicated FCE were significantly older than those isolated FCE ( = 0.015). The SFCT of the healthy subjects was significantly less than that of the fellow eyes of the patients with FCE ( < 0.01), as was that of the eyes with isolated FCE ( < 0.001) and complicated FCE ( < 0.001). The width of excavation was wider in eyes with complicated FCE than in those with isolated FCE ( = 0.001). Hypertransmission defect (HD) was found beneath 15 excavations and was more prevalent in the complicated FCE group than the isolated FCE group ( = 0.023).
Focal choroidal excavation appears to be closely related to chorioretinal disorders, and the width of the excavation is a significant indicator for evaluating the risk of chorioretinal diseases.
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
探讨局限性脉络膜凹陷（FCE）患者的危险因素及其与脉络膜视网膜疾病的相关性。
回顾性横断面研究。
纳入FCE患者，同时招募健康受试者作为对照组。
本研究收集了人口统计学信息、临床特征和多模态图像。使用光谱域光学相干断层扫描（SD-OCT）识别的FCE参数，通过内置软件进行手动测量，随后进行统计学分析。
使用OCT软件中的内置卡尺手动测量黄斑中心凹下脉络膜厚度（SFCT）、凹陷下脉络膜厚度（SECT）以及每个凹陷的最大深度和宽度。
本研究纳入了21例FCE患者（男13例/女8例）。平均年龄为45.2岁，最佳矫正视力（BCVA）为0.4最小分辨角对数（Snellen等效值，20/50）。21例患者的28只眼中存在局限性脉络膜凹陷，包括孤立性FCE（12只眼）和合并脉络膜新生血管（sCNV）、中心性浆液性脉络膜视网膜病变及其他情况的复杂性FCE（16只眼）。复杂性FCE患者的年龄显著大于孤立性FCE患者（P = 0.015）。健康受试者的SFCT显著低于FCE患者对侧眼（P < 0.01），孤立性FCE眼（P < 0.001）和复杂性FCE眼（P < 0.001）也是如此。复杂性FCE眼的凹陷宽度比孤立性FCE眼更宽（P = 0.001）。在15个凹陷下方发现了高透射缺陷（HD），且在复杂性FCE组中比孤立性FCE组更常见（P = 0.023）。
局限性脉络膜凹陷似乎与脉络膜视网膜疾病密切相关，凹陷宽度是评估脉络膜视网膜疾病风险的重要指标。
在本文末尾的脚注和披露中可能会发现专有或商业披露信息。
