Pihl Eva Vibeke Kofoed
Roskilde University, Roskilde, Denmark.
Soc Stud Sci. 2025 Feb;55(1):109-130. doi: 10.1177/03063127241268772. Epub 2024 Aug 16.
Drawing on ethnographic fieldwork, this paper unfolds the past and present uses of pigs that structured the emergence of a pig model of gut-hormone based appetite control, leading to the current scientific breakthrough in treatment of obesity. While the hyping of next generation medications for obesity and type 2 diabetes centers on the efficacy and profits attached to these drugs, I unfold how science embedded in this development had the in-vivo and in-vitro travels of Bettie-an obese Göttingen Minipig pig-at its heart. Tracing how she became embedded in a circuit of vitality connecting industrial agriculture and science on human health, I show how both are governed by a shared valuation of pigs' fat. Bettie's fat, however, was not to be eaten. Instead, Bettie was consumed in knowledge production. For pigs to enter this new trajectory, Bettie emerged as a promissory site for extraction of molecular information made possible by new visualization technologies and representational strategies that allowed for the coupling of human-pig physiology at the cellular level. While her travels were spurred by the hope of discovery of small molecules, Bettie allows us to grasp an important shift in science, as the insights derived from her work emphasized the importance of physiology and the environment for human obesity. In doing so, she served as a visceral model. On a larger scale, Bettie's entering science on human health reflects a recursive structure of knowledge in which the present problems with obesity and type 2 diabetes derive from the solutions to previous problems associated with alleviating hunger.
基于人种志田野调查,本文阐述了猪在过去和现在的用途,这些用途构成了基于肠道激素的食欲控制猪模型的出现,从而带来了目前肥胖症治疗方面的科学突破。虽然针对肥胖症和2型糖尿病的下一代药物炒作集中在这些药物的疗效和利润上,但我将揭示这一发展背后的科学如何以贝蒂——一只肥胖的哥廷根小型猪——在体内和体外的经历为核心。通过追溯她如何融入连接工业化农业和人类健康科学的活力循环,我展示了两者如何受到对猪脂肪的共同估值的支配。然而,贝蒂的脂肪不是用来吃的。相反,贝蒂在知识生产中被“消耗”了。为了让猪进入这个新轨迹,贝蒂成为了一个有望提取分子信息的场所,这得益于新的可视化技术和表征策略,这些技术和策略使得在细胞水平上实现人类与猪的生理耦合成为可能。虽然她的经历是由发现小分子的希望所推动的,但贝蒂让我们理解了科学中的一个重要转变,因为从她的工作中获得的见解强调了生理学和环境对人类肥胖的重要性。在这个过程中,她充当了一个实体模型。从更大的范围来看,贝蒂进入人类健康科学领域反映了一种知识的递归结构,即目前肥胖症和2型糖尿病的问题源于之前缓解饥饿问题的解决方案。