拓展对僵人综合征的认识：来自印度17例病例的见解
Expanding the Understanding of Stiff-Person Syndrome: Insights from 17 Cases in India.
作者信息
Jain Rajendra S, Pemawat Ashish, Sharma Pankajkumar, Nehra Kuldeep
机构信息
Department of Neurology, University S.M.S Medical College and Hospital, Jaipur, Rajasthan, India.
出版信息
Ann Indian Acad Neurol. 2024 Jul 1;27(4):419-425. doi: 10.4103/aian.aian_92_24. Epub 2024 Aug 16.
Abstract
Stiff-person syndrome (SPS) is a rare and complex neurologic disorder characterized by progressive muscle stiffness, painful spasms, and gait difficulties. In this report, we describe a case of SPS who presented with a relapse while on maintenance immunosuppressive treatment. In addition, we review the literature of 16 previously reported cases of SPS from India, highlighting the diverse clinical features, comorbidities, treatment response, and relapse. The occurrence of paraneoplastic SPS emphasizes the need for early recognition and diagnosis.
摘要
僵人综合征（SPS）是一种罕见且复杂的神经系统疾病，其特征为进行性肌肉僵硬、疼痛性痉挛和步态困难。在本报告中，我们描述了1例在维持性免疫抑制治疗期间复发的SPS病例。此外，我们回顾了印度此前报道的16例SPS病例的文献，突出了其多样的临床特征、合并症、治疗反应及复发情况。副肿瘤性SPS的发生强调了早期识别和诊断的必要性。
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本文引用的文献
1
F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Muscle Uptake in Antiglutamic Acid Decarboxylase Antibody-positive Stiff-person Syndrome.F-18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描在抗谷氨酸脱羧酶抗体阳性僵人综合征中的肌肉摄取情况
Indian J Nucl Med. 2023 Apr-Jun;38(2):162-164. doi: 10.4103/ijnm.ijnm_94_22. Epub 2023 Jun 8.
2
Brachial monomelic amyotrophy as an initial manifestation of stiff person syndrome.臂丛单肢肌萎缩作为僵人综合征的初始表现
J Neurosci Rural Pract. 2022 Oct-Dec;13(4):778-780. doi: 10.25259/JNRP-2022-3-24. Epub 2022 Dec 2.
3
Stiff-Person Syndrome: A Treatment Update and New Directions.僵人综合征：治疗进展与新方向
Cureus. 2020 Dec 9;12(12):e11995. doi: 10.7759/cureus.11995.
4
Neurological Syndromes Associated with Anti-GAD Antibodies.与抗 GABA 抗体相关的神经综合征。
Int J Mol Sci. 2020 May 24;21(10):3701. doi: 10.3390/ijms21103701.
5
A Case of Anti-glutamic Acid Decarboxylase-65 Antibody Positive Stiff Person Syndrome Presenting Initially as Acute Peripheral Vestibulopathy, Leading to Delayed Diagnosis After Multiple Hospitalizations.一例最初表现为急性周围性前庭病的抗谷氨酸脱羧酶65抗体阳性僵人综合征，经多次住院后导致诊断延迟。
Cureus. 2019 Nov 6;11(11):e6083. doi: 10.7759/cureus.6083.
6
Quantitative clinical and autoimmune assessments in stiff person syndrome: evidence for a progressive disorder.僵人综合征的定量临床和自身免疫评估：一种进行性疾病的证据
BMC Neurol. 2019 Jan 3;19(1):1. doi: 10.1186/s12883-018-1232-z.
7
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J Assoc Physicians India. 2015 Aug;63(8):81-2.
8
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Curr Opin Neurol. 2016 Aug;29(4):496-506. doi: 10.1097/WCO.0000000000000351.
9
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Ann Indian Acad Neurol. 2016 Jan-Mar;19(1):146-9. doi: 10.4103/0972-2327.165462.
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