Journel H, Milon J, Dabadie A, Parent P, Roussey M, Le Marec B
Pediatrie. 1985 Sep;40(6):461-8.
We report a clinical analysis of 327 cases of Spina Bifida and 102 cases of Anencephaly in Brittany. Maternal age, parity, birth weight are not different from random population. Male rate is 0.40 for Anencephaly and 0.50 for Spina Bifida. The study of pregnancies shows an increased frequency of hydramnios during anencephaly pregnancies (0.34) and high rate of abnormalities during the pregnancy of Spina Bifida (0.34) or Anencephaly (0.86). Four mothers of Spina Bifida were taking valproic acid. Thirty children (0.07) had other malformations.
我们报告了对布列塔尼地区327例脊柱裂和102例无脑儿的临床分析。产妇年龄、产次、出生体重与随机人群无差异。无脑儿的男性比例为0.40，脊柱裂为0.50。对妊娠情况的研究表明，无脑儿妊娠期间羊水过多的发生率增加（0.34），脊柱裂（0.34）或无脑儿（0.86）妊娠期间异常发生率较高。4名脊柱裂患儿的母亲正在服用丙戊酸。30名儿童（0.07）有其他畸形。
