Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany.
Faculty of Engineering, National University of Mar del Plata, Mar del Plata, Argentina.
Biomed Mater. 2024 Sep 3;19(6). doi: 10.1088/1748-605X/ad7084.
Electrospinning is a versatile and straightforward technique to produce nanofibrous mats with different morphologies. In addition, by optimizing the solution, processing, and environmental parameters, three-dimensional (3D) nanofibrous scaffolds can also be created using this method. In this work, the preparation and characterization of bioactive glass (BG) scaffolds based on the SiO-CaO sol-gel system, a biomaterial with a highly reactive surface, is reported. The electrospinning technique was combined with sol-gel methods to obtain nanofibrous 3D cotton wool-like scaffolds. The addition of zinc and copper ions to the silica-calcia system was examined, and the influence of these ions on the material properties and characteristics was investigated by various characterization techniques, from morphological and chemical properties to antibacterial and wound closure capability, cell viability and ion release. Our findings show that the cotton wool-like ion-doped nanofibers are promising for wound healing applications.
静电纺丝是一种通用且简单的技术，可用于生产具有不同形态的纳米纤维垫。此外，通过优化溶液、处理和环境参数，还可以使用这种方法创建三维（3D）纳米纤维支架。在这项工作中，报告了基于 SiO-CaO 溶胶-凝胶体系的生物活性玻璃（BG）支架的制备和表征，该体系是一种具有高反应性表面的生物材料。静电纺丝技术与溶胶-凝胶方法相结合，获得了纳米纤维 3D 棉花状支架。研究了在硅钙体系中添加锌和铜离子，并通过各种表征技术研究了这些离子对材料性能和特性的影响，从形态和化学性质到抗菌和伤口闭合能力、细胞活力和离子释放。我们的研究结果表明，棉花状离子掺杂纳米纤维在伤口愈合应用中具有广阔的前景。
