Center for Proteomic and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil, 28106Catholic University of Brası́lia, Brası́lia, Brazil.
Laboratory of Molecular Exercise Physiology - Physical Education Department, University Center - UDF, Brası́lia, Brazil.
Benef Microbes. 2024 Aug 14;15(6):565-587. doi: 10.1163/18762891-bja00031.
This systematic review aimed to compile various research designs, including experimental, longitudinal, cross-sectional, and case studies in humans and experimental studies in rodents, to examine changes in Akkermansia muciniphila abundance in response to exercise. This comprehensive approach can improve our understanding of A. muciniphila response to physical exercise and highlight gaps in the literature, providing valuable insights for future microbiome research. Four databases (Web of Science, PubMed, Scopus, and Sports Discuss) were searched in the literature. Quality assessment was conducted independently and in duplicate using two risk-of-bias tools (Downs and Black for human studies and SYRCLE's risk of bias for animal studies). 3,901 studies were identified, with thirteen human studies and nine animal studies included after screening. Of the thirteen human studies analysed, five (38.5%) were cross-sectional, seven (53.8%) were longitudinal/experimental, and one (7.7%) was a case study. These studies included 522 participants, among whom 157 were athletes, such as rugby players, marathon runners, triathletes, and skiers. Six studies reported an increase in A. muciniphila, five showed a decrease, and two found no significant differences. Regarding interventions, two studies used a combination of moderate-intensity strength and aerobic training, while seven used low to moderate-intensity aerobic exercises. In the nine rodent studies, eight (88.9%) were conducted on mice and one (11.1%) on rats, with all being experimental. These studies involved 310 animals. Eight studies reported a substantial increase in A. muciniphila, while one found no differences. Among these, eight employed moderate-intensity aerobic exercises as the intervention, and one utilised low-to-moderate-intensity strength training. The studies summarised in this review indicate that the impact of various physical exercise protocols on A. muciniphila abundance in humans remains controversial. However, rodent studies provide strong evidence that aerobic exercise increases A. muciniphila abundance in faecal pellets of both healthy and diseased models.
这篇系统综述旨在综合各种研究设计，包括人体的实验、纵向、横断面和病例研究以及啮齿动物的实验研究，以研究阿克曼氏菌属（Akkermansia）丰度在运动后的变化。这种全面的方法可以提高我们对阿克曼氏菌属对体育锻炼的反应的理解，并突出文献中的空白，为未来的微生物组研究提供有价值的见解。在文献中，我们在四个数据库（Web of Science、PubMed、Scopus 和 Sports Discuss）中进行了搜索。使用两个风险偏倚工具（Downs 和 Black 用于人体研究和 SYRCLE 的风险偏倚用于动物研究）独立且重复地进行了质量评估。确定了 3901 项研究，经过筛选后纳入了 13 项人体研究和 9 项动物研究。在分析的 13 项人体研究中，有 5 项（38.5%）是横断面研究，7 项（53.8%）是纵向/实验性研究，1 项（7.7%）是病例研究。这些研究共纳入了 522 名参与者，其中 157 名是运动员，如橄榄球运动员、马拉松运动员、三项全能运动员和滑雪者。有 6 项研究报告阿克曼氏菌属增加，5 项研究报告减少，2 项研究报告无显著差异。关于干预措施，有两项研究使用了中等强度的力量和有氧运动相结合，有七项研究使用了低到中等强度的有氧运动。在 9 项啮齿动物研究中，有 8 项（88.9%）是在小鼠身上进行的，1 项（11.1%）是在大鼠身上进行的，都是实验性研究。这些研究共涉及 310 只动物。有 8 项研究报告阿克曼氏菌属大量增加，1 项研究报告无差异。其中，8 项研究采用中等强度的有氧运动作为干预措施，1 项研究采用低到中等强度的力量训练。本综述中总结的研究表明，各种体育锻炼方案对人体阿克曼氏菌属丰度的影响仍存在争议。然而，啮齿动物研究提供了强有力的证据表明，有氧运动可增加健康和患病模型粪便样本中阿克曼氏菌属的丰度。
