多囊卵巢综合征（PCOS）女性的抑郁、更高水平的紧张诱导以及对应激的应对策略受损，与高雄激素血症的临床和实验室指标相关，而与中心性肥胖和胰岛素抵抗无关。
Depression, higher level of tension induction, and impaired coping strategies in response to stress in women with PCOS correlate with clinical and laboratory indices of hyperandrogenism and not with central obesity and insulin resistance.
作者信息
Dutkiewicz Edyta, Rachoń Dominik, Dziedziak Miłosz, Kowalewska Agnieszka, Moryś Joanna
机构信息
Department of Clinical and Experimental Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211, Gdańsk, Poland.
Private Outpatient Clinic, Słonimskiego 8/50, 80-280, Gdańsk, Poland.
出版信息
Arch Womens Ment Health. 2025 Apr;28(2):339-348. doi: 10.1007/s00737-024-01500-x. Epub 2024 Aug 17.
UNLABELLED
PCOS is characterized by ovarian hyperandrogenism and insulin resistance (IR), which give rise to symptoms of hyperandrogenism and central obesity, which in turn may cause depression, lower self-esteem, and deteriorate coping strategies in stressful situations.
THE PURPOSE
to examine the mental condition, self-esteem, and ways of coping with stress in women with PCOS compared to age and BMI-matched healthy controls and to correlate them with clinical and laboratory hyperandrogenism, central obesity, and IR.
METHODS
42 women with PCOS and 39 controls were assessed for the above-mentioned psychological measures and correlated with serum hormonal and metabolic parameters.
RESULTS
Compared to controls, women with PCOS had more symptoms of depression (p = 0.026), a higher level of tension induction (p = 0.032), were more prone to alcohol consumption (p = 0.015), and were less likely to use the strategy of active coping in stressful situations (p = 0.014) and to seek instrumental (p = 0.048) and emotional support (p = 0.043). The presence of hirsutism correlated negatively with the level of emotional induction (R = -0.32, p < 0.05), and androgenic alopecia positively with the hedonistic tone (R = 0.36, p < 0.05). Serum testosterone (TST) correlated positively with the likelihood of seeking instrumental support in stressful situations (R = 0.31, p < 0.05) and with emotional focus (R = 0.34, p < 0.05). Serum androstenedione (A4-dione) correlated negatively with the escape behavior (R = -0.32, p < 0.05). No correlations were found between waist circumference and IR with the studied psychological measures.
CONCLUSIONS
Women with PCOS are characterized by depression, higher levels of tension induction, and impaired coping strategies in stressful situations, which correlate with clinical and laboratory indices of hyperandrogenism and not with central obesity and IR.
未标注
多囊卵巢综合征（PCOS）的特征是卵巢雄激素过多和胰岛素抵抗（IR），这会导致高雄激素血症和中心性肥胖症状，进而可能导致抑郁、自尊心降低，并使在压力情况下的应对策略恶化。
目的
与年龄和体重指数（BMI）匹配的健康对照相比，研究PCOS女性的心理状况、自尊以及应对压力的方式，并将它们与临床和实验室高雄激素血症、中心性肥胖及IR相关联。
方法
对42名PCOS女性和39名对照进行上述心理测量，并与血清激素和代谢参数相关联。
结果
与对照组相比，PCOS女性有更多抑郁症状（p = 0.026）、更高的紧张诱导水平（p = 0.032），更倾向于饮酒（p = 0.015），在压力情况下采用积极应对策略的可能性更小（p = 0.014），寻求工具性支持（p = 0.048）和情感支持（p = 0.043）的可能性也更小。多毛症的存在与情感诱导水平呈负相关（R = -0.32，p < 0.05），雄激素性脱发与享乐主义基调呈正相关（R = 0.36，p < 0.05）。血清睾酮（TST）与在压力情况下寻求工具性支持的可能性呈正相关（R = 0.31，p < 0.05），与情感关注呈正相关（R = 0.34，p < 0.05）。血清雄烯二酮（A4-二酮）与逃避行为呈负相关（R = -0.32，p < 0.05）。腰围和IR与所研究的心理测量之间未发现相关性。
结论
PCOS女性的特征是抑郁、更高的紧张诱导水平以及在压力情况下受损的应对策略，这些与高雄激素血症的临床和实验室指标相关，而与中心性肥胖和IR无关。
Zotero 插件