Cingoranelli Shelbie J, Burnett Logan, Putnam Emily, Lapi Suzanne E
Department of Chemistry, University of Alabama at Birmingham, USA; Department of Radiology, University of Alabama at Birmingham, USA.
Department of Radiology, University of Alabama at Birmingham, USA; Department of Physics, University of Alabama at Birmingham, USA.
Appl Radiat Isot. 2024 Oct;212:111469. doi: 10.1016/j.apradiso.2024.111469. Epub 2024 Aug 6.
Scandium-47 is a promising radionuclide for targeted radiotherapy and is also an elementally matched therapeutic partner to Sc and Sc, which are suitable for Positron Emission Tomography. The predominantly reported routes for the production of Sc employ expensive enriched titanium or calcium targets to achieve high radionuclidic purity. This study reports measurements of the excitation function of the V(p,x)Sc reaction at proton energies of 18-24 MeV to optimize bombardment parameters for the production of Sc using this promising approach. The cross-sections reported here demonstrate that irradiation of vanadium targets can produce >99% radionuclidically pure Sc with a proton energy of 24 MeV, albeit at modest yields.
钪-47是一种很有前景的用于靶向放射治疗的放射性核素，也是与钪和钪元素匹配的治疗伙伴，适用于正电子发射断层扫描。目前报道的主要用于生产钪的途径采用昂贵的富集钛或钙靶来实现高放射性核素纯度。本研究报告了在18 - 24 MeV质子能量下对V(p,x)Sc反应激发函数的测量，以优化使用这种有前景的方法生产钪的轰击参数。此处报道的截面表明，用24 MeV的质子能量辐照钒靶可以产生放射性核素纯度>99%的钪，尽管产率不高。
