Division of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra, India; Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India.
Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, World Health Organisation, Lyon, France.
Cancer Epidemiol. 2024 Oct;92:102644. doi: 10.1016/j.canep.2024.102644. Epub 2024 Aug 16.
This study aimed to investigate the association between lifetime occupational history and risk of buccal mucosa cancer (BMC).
We utilized a multi-centric, hospital-based case-control study across five centres of Tata Memorial Centre, Mumbai, India. Cases included men aged 20-75-years with histological confirmed primary cancer of the buccal mucosa. Visitor controls were frequency matched to cases for age (10 years interval) and current residential zone. Study participants were interviewed face-to-face. Logistic regression was performed to estimate odds ratio (OR) and 95 % confidence intervals (CI).
Among ever employed males, we identified 1969 BMC cases and 2145 controls. We observed an increased risk of BMC in 'Craft and Related Trades Workers' (OR 1.37; 95 % CI 1.13-1.65), 'Plant and Machine Operators and Assemblers' (OR: 1.26; 95 % CI 1.01-1.56), and 'Elementary Occupations' (OR:1.33; 95 % CI 1.12-1.58). More specifically, the increased risk was observed for 'Metal, Machinery and Related Trades Workers', 'Handicraft and Printing Workers', 'Drivers and Mobile Plant Operators', and 'Laborers in Mining, Construction, Manufacturing and Transport'.
Our findings suggest that certain occupations may be at a higher risk of BMC. Some fraction of BMC can be prevented by reducing exposure to hazardous agents used in these occupations. Further research is needed to identify which exposures are responsible for the increased risk. Moreover, tobacco control and early detection activities can be focused towards these occupations as tobacco consumption is also high in them, which may also be the reason for increased risk observed in these groups.
本研究旨在探讨终生职业史与颊黏膜癌（BMC）风险之间的关联。
我们在印度塔塔纪念中心的五个中心进行了一项多中心、基于医院的病例对照研究。病例包括年龄在 20-75 岁之间、经组织学证实患有颊黏膜原发性癌症的男性。访客对照按年龄（10 年间隔）和当前居住区域与病例进行频数匹配。研究参与者接受了面对面访谈。使用逻辑回归来估计比值比（OR）和 95%置信区间（CI）。
在有过工作经历的男性中，我们确定了 1969 例 BMC 病例和 2145 例对照。我们观察到“手工艺和相关行业工人”（OR 1.37；95%CI 1.13-1.65）、“工厂和机器操作员及装配工”（OR：1.26；95%CI 1.01-1.56）和“体力劳动者”（OR：1.33；95%CI 1.12-1.58）患 BMC 的风险增加。更具体地说，“金属、机械和相关行业工人”、“手工艺和印刷工人”、“驾驶员和移动设备操作员”以及“采矿、建筑、制造和运输行业的工人”中观察到的风险增加更为明显。
我们的研究结果表明，某些职业可能面临更高的 BMC 风险。通过减少这些职业中使用的危险物质的暴露，可以预防一部分 BMC。需要进一步研究以确定哪些暴露是导致风险增加的原因。此外，可以将烟草控制和早期检测活动的重点放在这些职业上，因为这些职业中的烟草消费也很高，这也可能是这些群体中观察到的风险增加的原因。
