Bayer O, Cámara R, Zeissig S R, Ressing M, Dietz A, Locati L D, Ramroth H, Singer S
Division of Epidemiology and Health Services Research, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre, Johannes Gutenberg University, Obere Zahlbacher Straße 69, 55131, Mainz, Germany.
Cancer Registry of Rhineland-Palatinate, Mainz, Germany.
Eur Arch Otorhinolaryngol. 2016 Jan;273(1):9-20. doi: 10.1007/s00405-014-3321-y. Epub 2014 Oct 14.
The aim of the study was to explore the relationship between occupational exposure, defined by occupational categories and job title, and laryngeal cancer. A systematic review and meta-analysis of 21 tobacco and alcohol-adjusted case-control studies including data from 6,906 exposed cases and 10,816 exposed controls was performed to investigate the frequency of laryngeal cancer in different occupations. Job classifications were harmonized using the International Standard Classification of Occupations. Pooled odds ratios (OR [95 % confidence intervals (CI)]) were calculated for the different occupational groups. A significantly increased risk of laryngeal cancer was observed for the occupational category of 'production-related workers, transport equipment operators, and laborers' (OR=1.3 [1.2-1.4]); particularly at risk were occupations as: miners (OR=1.6 [1.2-2.1]), tailors (OR=1.7 [1.2-2.3]), blacksmith and toolmakers (OR=1.5 [1.2-1.7]), painters (OR=1.4 [1.1-1.9]), bricklayers and carpenters (OR=1.3 [1.2-1.5]), and transport equipment operators (OR=1.3 [1.2-1.5]). Individuals working as 'professional, technical, and related workers' (OR=0.7 [0.6- 0.8]), 'administrative and managerial workers' (OR=0.6 [0.4-0.7]), or 'clerical and related workers' (OR=0.8 [0.7-0.9]) had laryngeal cancer less frequently. Occupational exposure, defined by occupational categories and job title, is likely to be an independent risk factor for laryngeal cancer. Further research on specific occupations with increased risk of laryngeal cancer is warranted to explore the underlying mechanisms.
该研究的目的是探讨由职业类别和职称定义的职业暴露与喉癌之间的关系。对21项经烟草和酒精调整的病例对照研究进行了系统评价和荟萃分析，这些研究纳入了6906例暴露病例和10816例暴露对照的数据，以调查不同职业中喉癌的发病频率。职业分类采用国际职业标准分类进行统一。计算了不同职业组的合并比值比（OR[95%置信区间（CI）]）。观察到“生产相关工人、运输设备操作员和劳动者”职业类别患喉癌的风险显著增加（OR=1.3[1.2-1.4]）；尤其高危的职业有：矿工（OR=1.6[1.2-2.1]）、裁缝（OR=1.7[1.2-2.3]）、铁匠和工具制造工（OR=1.5[1.2-1.7]）、油漆工（OR=1.4[1.1-1.9]）、砌砖工和木匠（OR=1.3[1.2-1.5]）以及运输设备操作员（OR=1.3[1.2-1.5]）。从事“专业、技术及相关工作者”（OR=0.7[0.6-0.8]）、“行政和管理人员”（OR=0.6[0.4-0.7]）或“文书及相关工作者”（OR=0.8[0.7-0.9]）的个体患喉癌的频率较低。由职业类别和职称定义的职业暴露可能是喉癌的一个独立危险因素。有必要对喉癌风险增加的特定职业进行进一步研究，以探索其潜在机制。
